국립암센터 / Unurjargal Bayasgalan, 서양권*
Abstract
Herein, we investigated the dosimetric benefits for proton beam therapy (PBT) over modern photon radiation techniques according to tumor location (central, peripheral, and close to the chest wall) for stage I non-small cell lung cancer (NSCLC) patients. A total of 42 patients with stage I NSCLC were treated with PBT with a total dose of 50-70 Gy in four or 10 fractions considering the risk of treatment-related toxicities. Simulation plans for three-dimensional conformal radiation therapy (3D-CRT), static-field intensity-modulated radiotherapy (IMRT), and volumetric-modulated arc therapy (VMAT) were retrospectively generated using the same treatment volumes as implemented in the PBT plans for these patients. Dosimetric improvements were observed with PBT as compared with all the photon-based radiation techniques with regards to the mean lung dose, lung V5 and V10, mean heart dose, and heart V5 and V10 in all locations. Moreover, lower radiation exposure to the chest wall was observed within PBT for peripherally located and close to the chest wall tumors. All radiotherapy modalities achieved clinically satisfactory treatment plans in the current study. Notably, the usage of PBT resulted in significant dosimetric improvements in the lung and heart over photon-based techniques at all tumor locations, including the periphery, for stage I NSCLC.
Affiliations
Unurjargal Bayasgalan 1 2 , Sung Ho Moon 1 , Tae Hyun Kim 1 , Tae Yoon Kim 1 , Seung Hyun Lee 1 , Yang-Gun Suh 1
1 Proton Therapy Center, Research Institute and Hospital, National Cancer Center, Goyang 10408, Korea.
2 Department of Radiation Oncology, National Cancer Center, Ulaanbaatar 13370, Mongolia.
편집위원
stage I NSCLC에서 morden RT techniques 이용시 OAR constraints를 만족할 수 있지만 양성자치료시 lung & heart sparing에 보다 유용하므로 기저질환에 따라 추가적인 선량 감소가 필요한 경우 참고할만한 연구입니다.
2022-01-14 15:43:13