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  • [PLoS One.] Analysis of PET parameters predicting response to radiotherapy for myeloid sarcoma

    가톨릭대 / 최규혜, 송진호, 장홍석*

  • 출처
    PLoS One.
  • 등재일
    2021 Dec 20
  • 저널이슈번호
    16(12):e0261550. doi: 10.1371/journal.pone.0261550. eCollection 2021.
  • 내용

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    Abstract
    Purpose: Positron-emission tomography (PET)-CT has recently been used for diagnostic imaging and radiotherapy for myeloid sarcoma, but there is little research on predicting the response of radiotherapy. The aim of this study was to analyze the association between PET-CT variables and the response to radiotherapy in patients with myeloid sarcoma.

    Materials and methods: This study was conducted in myeloid sarcoma patients who received radiotherapy and PET-CT before and after radiotherapy. The response to radiotherapy was evaluated based on the European Organization for Research and Treatment of Cancer PET response criteria, and binary regression analysis was performed to assess the factors predicting reductions in the maximum standardized uptake value (SUVmax).

    Results: Twenty-seven sites in 12 patients were included in the study. Complete metabolic responses were seen in 24 patients after radiotherapy, a partial metabolic response in one, and progressive metabolic disease in two patients. The prescribed dose of more than 3000 cGy10 was significantly greater in the treatment control group (P = 0.024). In binary logistic regression analysis predicting reductions in the SUVmax of more than 70% after radiotherapy, the pretreatment SUVmax (≥ 7.5) and further chemotherapy after radiotherapy showed significant differences in univariate and multivariate analyses.

    Conclusion: Good metabolic responses (complete or partial) to radiotherapy were achieved in 92.6% of the myeloid sarcoma patients. Radiation doses < 3000 cGy10 and increased SUVmax were related to treatment failure and high SUVmax before radiotherapy was a factor influencing SUVmax reduction. Further large-scale studies are needed.

     

     

    Affiliations

    Kyu Hye Choi  1 , Jin Ho Song  1 , Yoo-Kang Kwak  2 , Jong Hoon Lee  3 , Hong Seok Jang  1
    1 Department of Radiation Oncology, Seoul Saint Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
    2 Department of Radiation Oncology, Incheon Saint Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
    3 Department of Radiation Oncology, Saint Vincent's Hospital, chlrb2 College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

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