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  • [Thorac Cancer.] Impact of tumor size and location on lung dose difference between stereotactic body radiation therapy techniques for non-small cell lung cancer

    가톨릭의대 / 장성순*

  • 출처
    Thorac Cancer.
  • 등재일
    2021 Dec
  • 저널이슈번호
    12(24):3310-3318. doi: 10.1111/1759-7714.14203. Epub 2021 Oct 24.
  • 내용

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    Abstract
    Background: To evaluate the lung dose differences between three-dimensional conformal radiotherapy (3D-CRT) and intensity-modulated radiation therapy (IMRT) techniques for lung stereotactic body radiation therapy (SBRT) and the correlations with tumor characteristics, such as size and location.

    Methods: Dosimetric comparisons between the two SBRT techniques in high- and low- to intermediate-dose regions were retrospectively performed using four planning indices and lung-dose parameters in 31 lung tumors. The magnitude of differences in these parameters was analyzed with relation to the planning target volume (PTV) and location-related parameters.

    Results: The absolute differences between the two techniques in lung-dose parameters were small in both ipsilateral and bilateral lungs. The dosimetric differences were mainly correlated with the PTV rather than location-related parameters, with positive and negative correlations with the high-dose and intermediate-dose parameters, respectively. The distances from the ipsilateral lung centroid to the PTV center were not correlated with the differences in any of the lung-dose parameters. Additionally, the negative correlations with the MLD and V20 differences disappeared after applying a more rapid dose fall-off in the IMRT plans for tumors with small PTVs of ≤15 cc.

    Conclusions: Lung dose differences between the 3D-CRT and IMRT techniques for lung SBRT were mainly correlated with the PTV rather than location-related parameters. Together with the dosimetric benefit in high-dose lung regions of IMRT for larger tumors, the relative increases in the MLD and V20 for small-sized tumors could be reduced by applying a more rapid dose fall-off outside the PTV.

     

     

    Affiliations

    Seong Soon Jang  1 , Yohan Shin  2 , Suk Young Park  3 , Gil Ja Huh  1 , Young Jun Yang  4
    1 Department of Radiation Oncology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
    2 Department of Radiation Oncology, Daejeon St. Mary's Hospital, Daejeon, Republic of Korea.
    3 Department of Internal Medicine, Daejeon St. Mary's Hospital, Daejeon, Republic of Korea.
    4 Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

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