의학물리학

  • [Br J Radiol.] 영상 유도 소동물 방사선 치료 플랫폼에서의 동적 조사 전달에 의한 선량 페인팅 기술 개발 연구Dose painting by dynamic irradiation delivery on an image-guided small animal radiotherapy platform.

    Maastricht University Medical Center / Stefan J van Hoof*

  • 출처
    Br J Radiol.
  • 등재일
    2019 Mar
  • 저널이슈번호
    92(1095):20180744. doi: 10.1259/bjr.20180744. Epub 2019 Feb 12.
  • 내용

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    Abstract
    OBJECTIVE::
    Using synchronized three-dimensional stage translation and multiangle radiation delivery to improve conformality and homogeneity of radiation delivery to complexly shaped target volumes for precision preclinical radiotherapy.

    METHODS::
    A CT image of a mouse was used to design irradiation plans to target the spinal cord and an orthotopic lung tumour. A dose painting method is proposed that combines heterogeneous two-dimensional area irradiations from multiple beam directions. For each beam direction, a two-dimensional area was defined based on the projection of the target volume. Each area was divided into many single beam Monte Carlo simulations, based on radiochromic film characterization of a 2.4 mm beam of a commercial precision image-guided preclinical irradiation platform. Beam-on time optimization including all simulated beams from multiple beam directions was used to achieve clinically relevant irradiation objects. Dose painting irradiation plans were compared to irradiation plans using a fixed aperture and rotatable variable aperture collimator.

    RESULTS::
    Irradiation plans for the proposed dose painting approach achieved good target coverage, similar dose to avoidance structures in comparison with irradiation using a rotatable variable aperture collimator, and considerably less dose to avoidance volumes in comparison with irradiation using a non-rotatable fixed aperture collimator. Required calculations and beam-on times were considerably longer for the dose painting method.

    CONCLUSION::
    It was shown that the proposed dose painting strategy is a valuable extension to increase the versatility of current generation precision preclinical radiotherapy platforms. More conformal and homogeneous dose delivery may be achieved at the cost of increased radiation planning and delivery duration.

    ADVANCES IN KNOWLEDGE::
    More advanced radiation planning for image-guided preclinical radiotherapy platforms can improve target dose conformality and homogeneity with the use of optimized dynamic irradiations with synchronized couch translation. The versatility of these platforms can be increased without hardware modifications.

     


    Author information

    van Hoof SJ1, Verde JB1, Verhaegen F1.
    1
    1 Department of Radiation Oncology, (MAASTRO), GROW - School for Oncology and Developmental Biology, Maastricht University Medical Center , Maastricht , The Netherlands.

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