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  • [Pharmaceutics.] MRI 가이드 광 역학 암치료를 위한 HSA 코팅 자기 나노 입자HSA-Coated Magnetic Nanoparticles for MRI-Guided Photodynamic Cancer Therapy.

    Moscow Technological University / Ostroverkhov P*

  • 출처
    Pharmaceutics.
  • 등재일
    2018 Dec 17
  • 저널이슈번호
    10(4). pii: E284. doi: 10.3390/pharmaceutics10040284.
  • 내용

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    Abstract
    BACKGROUND:
    Photodynamic therapy (PDT) is a promising technique for cancer treatment; however, low tissue permeability for irradiating light and insufficient photosensitizer (PS) accumulation in tumors limit its clinical potential. Nanoparticles are engineered to improve selective drug delivery to tumor sites, but its accumulation is highly variable between tumors and patients. Identifying PS accumulation peak in a personalized manner is crucial for therapeutic outcome. Magnetic nanoparticles (MNPs) provide opportunity for tracking drug accumulation in dynamics using non-invasive magnetic resonance imaging (MRI). The purpose of the study was to evaluate MNP loaded with PS as a theranostic tool for treating cancer in mice xenograft colon cancer models.

    METHODS:
    MNPs coated with human serum albumin (HSA) were loaded with bacteriochlorine a. MRI, atomic emission spectroscopy (AES) and fluorescent imaging were used to study MNP and drug accumulation rates and dynamics in CT26 tumors. Tumor growth curves were evaluated in animals that received PDT at different time points upon MNP systemic injection.

    RESULTS:
    Peak MNP accumulation in tumors was detected by MRI 60 min post injection (pi) and the data were verified by AES and fluorescent imaging. Up to 17% of injected dose/g of tissue was delivered to malignant tissues 24 h after injection. Consistent with MRI predicted drug accumulation peak PDT performed 60 min after intravenous injection was more efficient in inhibiting tumor growth than treatment scheduled 30 min and 240 min pi.

    CONCLUSIONS:
    PS loading on HAS-coated MNPs is a perspective approach to increase drug delivery to tumor site. Tracking for MNP accumulation by MRI can be used to predict drug concentration peak in tumors and to adjust PDT time scheduling for improved antitumor response.

     


    Author information

    Ostroverkhov P1, Semkina A2, Naumenko V3, Plotnikova E4, Yakubovskaya R5, Vodopyanov S6, Abakumov A7, Majouga A8,9,10, Grin M11, Chekhonin V12, Abakumov M13,14.
    1
    Institute of Fine Chemical Technology, Moscow Technological University (MIREA), 86 Vernadsky Avenue, Moscow 119571, Russia. mrp_ost@mail.ru.
    2
    Department of Medical Nanobiotechnology, Pirogov Russian National Research Medical University, Ostrovitianov str. 1, Moscow 117997, Russia. alevtina.semkina@gmail.com.
    3
    Laboratory of Biomedical Nanomaterials, National Research Technological University "MISiS", Leninskiy Prospekt 4, Moscow 119049, Russia. naumenko.vict@gmail.com.
    4
    FSBI NMRRC of the Ministry of Health of the Russian Federation, 2-Y Botkinskiy Proyezd 3, Moscow 125284, Russia. plotnikovaekaterina62@gmail.com.
    5
    FSBI NMRRC of the Ministry of Health of the Russian Federation, 2-Y Botkinskiy Proyezd 3, Moscow 125284, Russia. raisayakub@yandex.ru.
    6
    Laboratory of Biomedical Nanomaterials, National Research Technological University "MISiS", Leninskiy Prospekt 4, Moscow 119049, Russia. stepan.vodopianov@yandex.ru.
    7
    Skolkovo Institute of Science and Technology, Nobelya Ulitsa 3, Moscow 121205, Russia. A.Abakumov@skoltech.ru.
    8
    Laboratory of Biomedical Nanomaterials, National Research Technological University "MISiS", Leninskiy Prospekt 4, Moscow 119049, Russia. alexander.majouga@gmail.com.
    9
    Dmitry Mendeleev University of Chemical Technology of Russia, Miusskaya sq., 9, Moscow 125047, Russia. alexander.majouga@gmail.com.
    10
    Department of Chemistry, Moscow State University, Leninskie Gory 1/3, Moscow 119991, Russia. alexander.majouga@gmail.com.
    11
    Skolkovo Institute of Science and Technology, Nobelya Ulitsa 3, Moscow 121205, Russia. michael_grin@mail.ru.
    12
    Department of Medical Nanobiotechnology, Pirogov Russian National Research Medical University, Ostrovitianov str. 1, Moscow 117997, Russia. chekhoninnew@yandex.ru.
    13
    Department of Medical Nanobiotechnology, Pirogov Russian National Research Medical University, Ostrovitianov str. 1, Moscow 117997, Russia. abakumov_ma@rsmu.ru.
    14
    Laboratory of Biomedical Nanomaterials, National Research Technological University "MISiS", Leninskiy Prospekt 4, Moscow 119049, Russia. abakumov_ma@rsmu.ru.

  • 키워드
    MRI; Photodynamic therapy; human serum albumin; iron oxide nanoparticles
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