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  • [Biochem Biophys Res Commun.] Developmental complex trauma induces the dysfunction of the amygdala-mPFC circuit in the serotonergic and dopaminergic systems

    [Biochem Biophys Res Commun.] Developmental complex trauma induces the dysfunction of the amygdala-mPFC circuit in the serotonergic and dopaminergic systems

    KIRAMS / 오세종, 최재용*

  • 출처
    Biochem Biophys Res Commun.
  • 등재일
    2022 Mar 16
  • 저널이슈번호
    605:104-110. doi: 10.1016/j.bbrc.2022.03.069.
  • 내용

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    Abstract
    Developmental complex trauma is strongly associated with various psychiatric disorders in adulthood. Multiple lines of evidence have demonstrated that the amygdala-mPFC circuit regulates emotion and plays an important role in stress reactions. However, most studies on developmental trauma have mainly focused on neurological aspects in biological, behavioral, and structural changes with regard to a single stressor. In the present study, after applying complex stressors to the developmental phase, we would like to elucidate the functional changes in amygdala-mPFC circuit in the dopaminergic and serotonergic systems in the adult brain. Here, maternal separation and restraint stress were used to generate the trauma. The results showed that the body weights and corticosterone levels of animals exposed to developmental trauma decreased when compared to controls. In the neuroendocrine aspect, trauma leads to changes in proinflammatory cytokines, resulting in a decrease in IL-β and an increase in TNF-α. In the neuroPET studies, the developmental trauma group displayed a reduction in serotonergic and dopaminergic PET uptake in the amygdala and mPFC. Collectively, our results indicate that developmental trauma weakens the serotonergic and dopaminergic systems in the amygdala-mPFC circuit.

     

     

    Affiliations

    Se Jong Oh  1 , Kyung Rok Nam  1 , Namhun Lee  1 , Kyung Jun Kang  1 , Kyo Chul Lee  1 , Yong Jin Lee  1 , Jae Yong Choi  2
    1 Division of Applied RI, Korea Institute of Radiological & Medical Sciences, 75 Nowon-ro, Nowon-gu, Seoul, South Korea.
    2 Division of Applied RI, Korea Institute of Radiological & Medical Sciences, 75 Nowon-ro, Nowon-gu, Seoul, South Korea; Radiological and Medico-Oncological Sciences, University of Science and Technology (UST), Seoul, South Korea. Electronic address: smhany@kirams.re.kr.

  • 키워드
    Amygdala-mPFC circuit; Developmental trauma; Dopamine; Positron emission tomography; Serotonin; Stress.
  • 연구소개
    발달기의 트라우마는 성인기의 다양한 정신 질환과 밀접하게 연관되어있습니다. 이에 대한 주요한 신경회로 중, 편도체-내측전전두엽 회로가 감정과 스트레스 반응을 조절하는 것으로 알려져 있습니다. 본 연구에서는 발달기 복합 트라우마가 체중감소뿐 아니라 염증촉진 사이토카인의 분비를 활성화하는 등 생리적 변화를 유도하고, 기능적으로는 편도체-내측전전두엽의 세로토닌계와 도파민계에 대한 방사성의약품의 섭취를 감소시키는 것을 확인할 수 있었습니다. 이를 통해 기존 단일 트라우마에 대한 연구에 더하여 발달기 트라우마의 정신병리에 대한 이해를 넓힌 것이 연구의 의의라 할 수 있습니다.
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