글로벌 연구동향
핵의학
- 2022년 09월호
[J Cardiovasc Imaging.] Evaluation of Non-infarct-Related Arteries Using C-11 Acetate PET in STEMI With Multivessel Disease전남대병원 / 조상건, 송호천*
- 출처
- J Cardiovasc Imaging.
- 등재일
- 2022 Jul
- 저널이슈번호
- 30(3):169-180. doi: 10.4250/jcvi.2021.0189.
- 내용
Abstract
Background: We analyzed whether C-11 acetate positron emission tomography (PET) can be used for the evaluation of non-infarct-related artery (NIRA) in patients with ST-elevation myocardial infarction (STEMI) and multivessel disease.Methods: We prospectively enrolled 31 patients with STEMI and at least one NIRA stenosis (diameter stenosis [DS] ≥ 50%). C-11 acetate PET was performed after successful revascularization for the infarct-related artery (IRA). Myocardial blood flow (MBF) and oxidative metabolism (kmono) were measured and compared between NIRA vs. IRA, stenotic (DS ≥ 50%) vs. non-stenotic (DS < 50%) NIRAs, and NIRAs with significant stenosis (DS ≥ 70% or fractional flow reserve [FFR] ≤ 0.80) vs. those without (neither DS ≥ 70% nor FFR ≤ 0.80). The correlations between PET and angiographic parameters were also analyzed.
Results: MBF and kmono were significantly higher in NIRAs than those in IRAs. Stenotic NIRAs showed significantly reduced stress MBF, myocardial flow reserve (MFR), relative flow reserve (RFR) (0.72 ± 0.12 vs. 0.82 ± 0.14; p = 0.001), and stress kmono, as compared to those in non-stenotic NIRAs. NIRAs with significant stenosis had significantly lower stress MBF, MFR, and RFR (0.70 ± 0.10 vs. 0.80 ± 0.14; p = 0.001). RFR showed the best, but modest linear correlation with DS of NIRA stenosis (r = -0.429, p = 0.001). RFR > 0.81 could effectively exclude the presence of significant NIRA stenosis.
Conclusions: C-11 acetate PET could be a feasible alternative noninvasive modality in patients with STEMI and multivessel disease, by excluding the presence of significant NIRA stenosis.
Affiliations
Sang-Geon Cho 1 , Minchul Kim 2 , Seung Hun Lee 2 , Ki Seong Park 1 , Jahae Kim 1 , Jang Bae Moon 1 , Ho-Chun Song 3
1 Department of Nuclear Medicine, Chonnam National University Hospital, Gwangju, Korea.
2 Department of Cardiology, Chonnam National University Hospital, Gwangju, Korea.
3 Department of Nuclear Medicine, Chonnam National University Hospital, Gwangju, Korea. songhc@jnu.ac.kr.
- 키워드
- Myocardial perfusion imaging; Oxygen consumption; Positron emission tomography; ST elevation myocardial infarction.
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