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  • [Cancers (Basel).] Proton Beam Therapy versus Photon Radiotherapy for Stage I Non-Small Cell Lung Cancer

    성균관의대, 국립암센터 / 서양권, 노재명, 표홍렬*, 문성호*

  • 출처
    Cancers (Basel).
  • 등재일
    2022 Jul 26
  • 저널이슈번호
    14(15):3627. doi: 10.3390/cancers14153627.
  • 내용

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    Abstract
    Proton beam therapy (PBT) and photon radiotherapy for stage I non-small cell lung cancer (NSCLC) were compared in terms of clinical outcomes and dosimetry. Data were obtained from patients who underwent PBT or photon radiotherapy at two institutions-the only two facilities where PBT is available in the Republic of Korea. Multivariate Cox proportional hazards models and propensity score-matched analyses were used to compare local progression-free survival (PFS) and overall survival (OS). Survival and radiation exposure to the lungs were compared in the matched population. Of 289 patients included in the analyses, 112 and 177 underwent PBT and photon radiotherapy, respectively. With a median follow-up duration of 27 months, the 2-year local PFS and OS rates were 94.0% and 83.0%, respectively. In the multivariate analysis, a biologically effective dose (BED10, using α/β = 10 Gy) of ≥125 cobalt gray equivalents was significantly associated with improved local PFS and OS. In the matched analyses, the local PFS and OS did not differ between groups. However, PBT showed significantly lower lung and heart radiation exposure in the mean dose, V5, and V10 than photon radiotherapy. PBT significantly reduced radiation exposure to the heart and lungs without worsening disease control in stage I NSCLC patients.

     

     

     

     

    Affiliations

    Yang-Gun Suh  1 , Jae Myoung Noh  2 , Doo Yeul Lee  1 , Tae Hyun Kim  1 , Unurjargal Bayasgalan  1   3 , Hongryull Pyo  2 , Sung Ho Moon  1
    1 Proton Therapy Center, Research Institute and Hospital, National Cancer Center, Goyang 10408, Korea.
    2 Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea.
    3 Department of Radiation Oncology, National Cancer Center, Ulaanbaatar 13370, Mongolia.

  • 키워드
    dosimetric comparison; hypofractionated radiotherapy; non-small cell lung cancer; proton beam therapy; stereotactic ablative radiotherapy; stereotactic body radiotherapy.
  • 편집위원

    국내에서 양성자치료가 가능한 두 개 기관에서 1기 비소세포성 폐암에 대한 proton Tx 및 photon Tx를 후향적으로 비교한 연구로 proton beam의 정상조직보호에 대한 선량학적 장점이 있지만 임상성적은 비슷한 양상을 보여주었습니다.

    2022-08-31 16:54:47

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