방사선종양학

본문글자크기
  • [In Vivo.] Role of Adjuvant Treatment in High-risk Patients Following Resection for Gallbladder Cancer

    한양의대 / 박영희, 박혜진*

  • 출처
    In Vivo.
  • 등재일
    Mar-Apr 2022
  • 저널이슈번호
    36(2):961-968. doi: 10.21873/invivo.12787.
  • 내용

    바로가기  >

    Abstract
    Aim: To identify prognostic factors for surgically resected gallbladder cancer (GBC).

    Patients and methods: Medical records of 66 patients with GBC undergoing potentially curative resection between 2001 and 2017 were retrospectively reviewed.

    Results: After a median follow-up of 39.9 months (range=0.5-216.4 months), 22 locoregional recurrences and 25 distant metastases occurred. Adjuvant radiotherapy and adjuvant chemotherapy failed to prove efficacy in all patient groups. In patients with stage III-IV GBC, adjuvant chemotherapy showed a marginally positive effect on locoregional control (p=0.064), and was significantly beneficial for overall survival (p=0.040), and adjuvant treatment improved both locoregional control and overall survival (p=0.029 and p=0.005, respectively). On multivariate analysis, a negative resection margin was a significant prognostic factor for superior local control, and disease-free and overall survival (p=0.003, p=0.010 and p=0.005, respectively) and adjuvant treatment was associated with improved overall survival (p=0.018).

    Conclusion: Adjuvant treatment is recommended for patients with stage III-IV GBC following curative surgical resection.

     

     

    Affiliations

    Younghee Park  1 , Kiryun Kim  2 , Hae Jin Park  3 , Ha-Jung Chun  4 , Dongho Choi  5 , Kyubo Kim  6
    1 Department of Radiation Oncology, Soonchunhyang University Seoul Hospital, Seoul, Republic of Korea.
    2 Hanyang University College of Medicine, Seoul, Republic of Korea.
    3 Department of Radiation Oncology, Hanyang University College of Medicine, Seoul, Republic of Korea; haejinpark@hanyang.ac.kr.
    4 Department of Radiation Oncology, Hanyang University College of Medicine, Seoul, Republic of Korea.
    5 Department of Surgery, Hanyang University College of Medicine, Seoul, Republic of Korea.
    6 Department of Radiation Oncology, Ewha Womans University College of Medicine, Seoul, Republic of Korea.

  • 키워드
    Gallbladder cancer; adjuvant chemotherapy; adjuvant radiotherapy; adjuvant treatment; prognostic factor.
  • 덧글달기
    덧글달기
       IP : 3.215.79.204

    등록