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Abstract
BACKGROUND:
Cancer treatment increases the risk of cardiovascular (CV) events. However, the long-term CV outcome of breast cancer patients who undergo radiotherapy and chemotherapy concomitantly is unknown. This study aimed to determine the incidence and risk factors of CV events among these patients.

METHODS:
Six hundred sixty consecutive breast cancer patients older than 50 years from November 2005 to September 2015, were enrolled in four university hospitals. The primary endpoint was CV events including CV mortality, myocardial infarction, heart failure, and stroke. CV events occurred in 14 (2.1%) patients during the follow-up period (median, 47.1 months).

RESULTS:
Left-side irradiation was associated with increased risk of CV events in patients with doxorubicin dose ≥250mg/m2 but not in patients with doxorubicin dose <250mg/m2. On multivariable analysis, concomitant left-side irradiation with doxorubicin dose ≥250mg/m2 and hypertension were independent risk factors for CV events.

CONCLUSION:
The risk of CV events was further increased with concomitant left-side irradiation and doxorubicin ≥250mg/m2 in breast cancer patients.

Author information

Kim DY1, Youn JC2, Park MS3, Lee S3, Choi SW3, Ryu KH3, Kim LS4, Shim MS5, Lee JJ6, Han S7.
1
Division of Cardiology, Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Hwaseong, Republic of Korea; Division of Cardiology, Korea University Anam Hospital, Seoul, Republic of Korea.
2
Division of Cardiology, Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Hwaseong, Republic of Korea. Electronic address: jong.chan.youn@gmail.com.
3
Division of Cardiology, Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Hwaseong, Republic of Korea.
4
Division of Breast and Endocrine Surgery, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Republic of Korea.
5
Department of Thoracic and Cardiovascular Surgery, Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Republic of Korea.
6
Department of Thoracic and Cardiovascular Surgery, Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Republic of Korea. Electronic address: jj58lee@hallym.or.kr.
7
Division of Cardiology, Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Hwaseong, Republic of Korea. Electronic address: hansw29@hallym.or.kr.