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  • [J Appl Clin Med Phys.] The development of a 4D treatment planning methodology to simulate the tracking of central lung tumors in an MRI-linac.

    University of Toronto / Keller BM*

  • 출처
    J Appl Clin Med Phys.
  • 등재일
    . 2018 Jan
  • 저널이슈번호
    19(1):145-155. doi: 10.1002/acm2.12233. Epub 2017 Dec 1.
  • 내용

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    Abstract
    PURPOSE:
    Targeting and tracking of central lung tumors may be feasible on the Elekta MRI-linac (MRL) due to the soft-tissue visualization capabilities of MRI. The purpose of this work is to develop a novel treatment planning methodology to simulate tracking of central lung tumors with the MRL and to quantify the benefits in OAR sparing compared with the ITV approach.

    METHODS:
    Full 4D-CT datasets for five central lung cancer patients were selected to simulate the condition of having 4D-pseudo-CTs derived from 4D-MRI data available on the MRL with real-time tracking capabilities. We used the MRL treatment planning system to generate two plans: (a) with a set of MLC-defined apertures around the target at each phase of the breathing ("4D-MRL" method); (b) with a fixed set of fields encompassing the maximum inhale and exhale of the breathing cycle ("ITV" method). For both plans, dose accumulation was performed onto a reference phase. To further study the potential benefits of a 4D-MRL method, the results were stratified by tumor motion amplitude, OAR-to-tumor proximity, and the relative OAR motion (ROM).

    RESULTS:
    With the 4D-MRL method, the reduction in mean doses was up to 3.0 Gy and 1.9 Gy for the heart and the lung. Moreover, the lung's V12.5 Gy was spared by a maximum of 300 cc. Maximum doses to serial organs were reduced by up to 6.1 Gy, 1.5 Gy, and 9.0 Gy for the esophagus, spinal cord, and the trachea, respectively. OAR dose reduction with our method depended on the tumor motion amplitude and the ROM. Some OARs with large ROMs and in close proximity to the tumor benefited from tracking despite small tumor amplitudes.

    CONCLUSIONS:
    We developed a novel 4D tracking methodology for the MRL for central lung tumors and quantified the potential dosimetric benefits compared with our current ITV approach.

     


    Author information

    Al-Ward SM1, Kim A1,2, McCann C1,2, Ruschin M1,2, Cheung P1,2, Sahgal A1,2, Keller BM1,2.
    1
    Sunnybrook Health Sciences Centre, Odette Cancer Centre, Toronto, ON, Canada.
    2
    Department of Radiation Oncology, University of Toronto, Toronto, ON, Canada.

     

  • 키워드
    4D treatment planning; MRI linac; SABR lung; central lung tumors; monaco TPS
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