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  • [Cancer Res.] A noninvasive tactic to quantify tumor burden in a deadly pediatric brainstem tumor offers a rapid treatment monitoring option that may help improve management of this cancer.

    Memorial Sloan Kettering Cancer Center / Thomas Reiner*

  • 출처
    Cancer Res.
  • 등재일
    2017 Apr 15
  • 저널이슈번호
    77(8):2112-2123. doi: 10.1158/0008-5472.CAN-16-2850. Epub 2017 Jan 20.
  • 내용

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    Abstract

    Diffuse intrinsic pontine glioma (DIPG) is a childhood brainstem tumor with a universally poor prognosis. Here, we characterize a positron emission tomography (PET) probe for imaging DIPG in vivo In human histological tissues, the probes target, PARP1, was highly expressed in DIPG compared to normal brain. PET imaging allowed for the sensitive detection of DIPG in a genetically engineered mouse model, and probe uptake correlated to histologically determined tumor infiltration. Imaging with the sister fluorescence agent revealed that uptake was confined to proliferating, PARP1-expressing cells. Comparison with other imaging technologies revealed remarkable accuracy of our biomarker approach. We subsequently demonstrated that serial imaging of DIPG in mouse models enables monitoring of tumor growth, as shown in modeling of tumor progression. Overall, this validated method for quantifying DIPG burden would serve useful in monitoring treatment response in early phase clinical trials.​ 

     

    Author information

    Kossatz S1, Carney B1,2, Schweitzer M3, Carlucci G1, Miloushev VZ1,4, Maachani UB3, Rajappa P3, Keshari KR1,4,5, Pisapia D6, Weber WA1,4, Souweidane MM3,7, Reiner T8,4.

    Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.

    Department of Chemistry, Hunter College and PhD Program in Chemistry, The Graduate Center of the City University of New York, New York, New York.

    Department of Neurological Surgery, Weill Cornell Medical College, New York, New York.

    Department of Radiology, Weill Cornell Medical College, New York, New York.

    Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York.

    Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, New York.

    Department of Neurosurgery, Memorial Sloan Kettering Cancer Center, New York, New York.

    Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York. reinert@mskcc.org. 

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