방사선의학 웹진

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Abstract

A combination therapy consisting of radiotherapy and chemotherapy is performed using the core/shell nanoparticles (NPs) containing gold NPs and doxorubicin (DOX). Gold NPs in the core/shell NPs were utilized as a radiosensitizer. To examine the morphology and size distribution of the core/shell NPs, transmittance electron microscopy and dynamic light scattering were used. The in vitro release behavior, cellular uptake and toxicity were also observed to verify the functionality of the core/shell NPs as a nanocarrier. To demonstrate the advantage of the core/shell NPs over traditional gold NPs reported in the combination therapy, we evaluated the accumulation behavior of the core/shell NPs at the tumor site using the biodistribution. Antitumor efficacy was observed with and without radiation to evaluate the role of gold NPs as a radiosensitizer. 

Author information

Kim K1, Oh KS1, Park DY1, Lee JY1, Lee BS2, Kim IS3, Kim K3, Kwon IC3, Sang YK2, Yuk SH4.​

1College of Pharmacy, Korea University, 2511 Sejongro, Sejong 339-700, Republic of Korea.

2Center for Theragnosis, Korea Institute of Science and Technology, 39-1 Hawolgok-dong, Sungbuk-gu, Seoul 136-791, Republic of Korea; Department of Otolaryngology, Asan Medical Center, University of Ulsan, College of Medicine, 388-1 Pungnap-dong, Songpa-gu, Seoul 138-736, Republic of Korea.

3Center for Theragnosis, Korea Institute of Science and Technology, 39-1 Hawolgok-dong, Sungbuk-gu, Seoul 136-791, Republic of Korea.

4College of Pharmacy, Korea University, 2511 Sejongro, Sejong 339-700, Republic of Korea. Electronic address: shyuk@korea.ac.kr.