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Abstract

This study was aimed to evaluate the effect of (124)I-labeling with hexadecyl-4-iodobenzoate (HIB) on gene expression related to cell cycle, DNA repair, transcription, proliferation and differentiation of adipose-derived stem cells (ADSCs). [(124)I]HIB showed high labeling efficiency with ADSCs (51.3±1.3%, 0.3-2.0Bq/cell) and there is no morphological change of ADSCs. In the microarray analysis of gene expression pattern, differences were not observed between non-labeled and [(124)I]HIB-labeled ADSCs. We demonstrated that (124)I-labeling with HIB did not affect the biological properties of ADSCs. 

Author information

Kim MH1, Lee KC2, An GI2, Woo SK2, Park NW3, Kim BI2, Eom KD3, Kim KI2, Lee TS2, Kim CW4, Yoo J5, Kang JH2, Lee YJ6.

1Molecular Imaging Research Center, Korea Institute of Radiological and Medical Sciences, Seoul, Republic of Korea; School of Life Sciences and Biotechnology, Korea University, Seoul, Republic of Korea.

2Molecular Imaging Research Center, Korea Institute of Radiological and Medical Sciences, Seoul, Republic of Korea.

3College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea.

4School of Life Sciences and Biotechnology, Korea University, Seoul, Republic of Korea.

5Department of Molecular Medicine, BK21 Plus KNU Biomedical Convergence Program, Kyungpook National University, Daegu, Republic of Korea.

6Molecular Imaging Research Center, Korea Institute of Radiological and Medical Sciences, Seoul, Republic of Korea. Electronic address: yjlee@kirams.re.kr.