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Abstract

The abnormal assembly of β-amyloid (Aβ) peptides into neurotoxic, β-sheet-rich amyloid aggregates is a major pathological hallmark of Alzheimer's disease (AD). Light-induced photosensitizing molecules can regulate Aβ amyloidogenesis. Multiple photochemical analyses using circular dichroism, atomic force microscopy, dot blot, and native gel electrophoresis verified that photoactivated meso-tetra(4-sulfonatophenyl)porphyrin (TPPS with M=2H(+) , Zn(2+) , Cu(2+) , Mn(2+) ) successfully inhibits Aβ aggregation in vitro. Furthermore, Aβ toxicity was relieved in the photoexcited-TPPS-treated Drosophila AD model. TPPS suppresses neural cell death, synaptic toxicity, and behavioral defects in the Drosophila AD model under blue light illumination. Behavioral phenotypes, including larval locomotion defect and short lifespan caused by Aβ overexpression, were also rescued by blue light-excited TPPS.

Author information

Lee BI1, Lee S2,3, Suh YS2, Lee JS1, Kim AK2, Kwon OY4, Yu K5, Park CB6.

1Department of Materials Science and Engineering, Korea Advanced Institute of Science and Technology, 335 Science Road, Daejeon 305-701 (Republic of Korea).

2Neurophysiology Research Group, Bionano Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Department of Functional Genomics, Korea University of Science and Technology (UST), Daejeon 305-333 (Korea).

3Gwangju Center, Korea Basic Science Institute (KBSI), Gwangju 500-757 (Korea).

4Department of Anatomy, College of Medicine, Chungnam National University, Daejeon 301-747 (Korea).

5Neurophysiology Research Group, Bionano Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Department of Functional Genomics, Korea University of Science and Technology (UST), Daejeon 305-333 (Korea). kweonyu@kribb.re.kr.

6Department of Materials Science and Engineering, Korea Advanced Institute of Science and Technology, 335 Science Road, Daejeon 305-701 (Republic of Korea). parkcb@kaist.ac.kr.