글로벌 연구동향
분자영상 및 방사화학
- 2019년 08월호
[J Control Release.] Thrombus targeting aspirin particles for near infrared imaging and on-demand therapy of thrombotic vascular diseases.충북대 / 이정훈, 이동원*
- 출처
- J Control Release.
- 등재일
- 2019 May 10
- 저널이슈번호
- 304:164-172. doi: 10.1016/j.jconrel.2019.05.012. [Epub ahead of print]
- 내용
Abstract
A blood clot (thrombus) is formed as a final product of the hemostatic process with two major components, a mesh of cross-linked fibrin and platelets activated by high concentration of hydrogen peroxide (H2O2). Thrombus formation impedes blood flow to brain and heart and is a principle cause of life-threatening diseases such as stroke and myocardial infarction. Aspirin has been widely used for the treatment and prevention of various cardiovascular diseases, but is unable to target a thrombus and scavenge a high level of H2O2. In this study, we report thrombus targeting aspirin polyconjugate particles (T-APP) as a near infrared imaging agent and on-demand therapeutic agent for thrombotic vascular diseases. T-APP were formulated from H2O2-activatable aspirin polyconjugate, fibrin-specific peptides and fluorescent IR780. In mouse models of tail bleeding and arterial thrombosis, T-APP targeted the thrombosed vessels rapidly with excellent specificity. T-APP also exerted highly strong antithrombotic activity in the thrombosed vessel by suppressing anti-inflammatory cytokines and inhibiting platelet activation. Based on the unique features such as specific thrombus targeting, H2O2 scavenging, and on-demand therapeutic actions, the rationally engineered T-APP have important ramifications on imaging and on-demand therapy of thrombotic disorders.
Author informationLee J1, Jeong L1, Jung E1, Ko C1, Seon S1, Noh J2, Lee D3.
1
Department of BIN Convergence Technology, Chonbuk National University, Baekjedaero 567, Jeonju, Chonbuk 54896, Republic of Korea.
2
Department of Polymer·Nano Science and Technology, Chonbuk National University, Baekjedaero 567, Jeonju, Chonbuk 54896, Republic of Korea.
3
Department of BIN Convergence Technology, Chonbuk National University, Baekjedaero 567, Jeonju, Chonbuk 54896, Republic of Korea; Department of Polymer·Nano Science and Technology, Chonbuk National University, Baekjedaero 567, Jeonju, Chonbuk 54896, Republic of Korea. Electronic address: dlee@chonbuk.ac.kr.
- 키워드
- Antiplatelet activity; Aspirin; Hydrogen peroxide; Polyconjugate; Thrombus
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