글로벌 연구동향
분자영상 및 방사화학
- 2017년 08월호
[Biomaterials.] Dextran sulfate nanoparticles as a theranostic nanomedicine for rheumatoid arthritis.성균관대/ 허로운, 유동길, 박재형*
- 출처
- Biomaterials.
- 등재일
- 2017 Jul
- 저널이슈번호
- 131:15-26. doi: 10.1016/j.biomaterials.2017.03.044. Epub 2017 Mar 26.
- 내용
Abstract
With the aim of developing nanoparticles for targeted delivery of methotrexate (MTX) to inflamed joints in rheumatoid arthritis (RA), an amphiphilic polysaccharide was synthesized by conjugating 5β-cholanic acid to a dextran sulfate (DS) backbone. Due to its amphiphilic nature, the DS derivative self-assembled into spherical nanoparticles (220 nm in diameter) in aqueous conditions. The MTX was effectively loaded into the DS nanoparticles (loading efficiency: 73.0%) by a simple dialysis method. Interestingly, the DS nanoparticles were selectively taken up by activated macrophages, which are responsible for inflammation and joint destruction, via scavenger receptor class A-mediated endocytosis. When systemically administrated into mice with experimental collagen-induced arthritis (CIA), the DS nanoparticles effectively accumulated in inflamed joints (12-fold more than wild type mice (WT)), implying their high targetability to RA tissues. Moreover, the MTX-loaded DS nanoparticles exhibited significantly improved therapeutic efficacy against CIA in mice compared to free MTX alone. Overall, the data presented here indicate that DS nanoparticles are potentially useful nanomedicines for RA imaging and therapy.
Author information
Heo R1, You DG2, Um W3, Choi KY4, Jeon S4, Park JS5, Choi Y6, Kwon S4, Kim K7, Kwon IC7, Jo DG6, Kang YM8, Park JH9.
1Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul 06351, Republic of Korea.2School of Chemical Engineering, College of Engineering, Sungkyunkwan University, Suwon 16419, Republic of Korea; Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea.3Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul 06351, Republic of Korea; Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea.4School of Chemical Engineering, College of Engineering, Sungkyunkwan University, Suwon 16419, Republic of Korea.5Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore 21231, United States.6School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea.7Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea.8School of Medicine, Kyungpook National University, Daegu 41566, Republic of Korea.9Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul 06351, Republic of Korea; School of Chemical Engineering, College of Engineering, Sungkyunkwan University, Suwon 16419, Republic of Korea. Electronic address: jhpark1@skku.edu.
- 키워드
- Dextran sulfate; Drug delivery; Macrophage; Nanoparticles; Rheumatoid arthritis
- 덧글달기
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편집위원
관절 염증(류마티스 관절염, RA) 표적 영상 및 치료에 관한 연구 논문으로, methotrexate(MTX) 약물이 주입된 dextran sulfate(DS) 나노입자(220 nm)의 개발 및 동물실험 결과를 보여주며 새로운 RA 영상 및 치료법을 제시해 주고 있다.
덧글달기닫기2017-08-03 16:57:50
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