글로벌 연구동향
분자영상 및 방사화학
- 2017년 07월호
[J Med Chem.] Gadolinium Complex of 1,4,7,10-Tetraazacyclododecane-1,4,7-trisacetic Acid (DO3A)-Ethoxybenzyl (EOB) Conjugate as a New Macrocyclic Hepatobiliary MRI Contrast Agent.경북대/백아람, 장용민*, 김태정*
- 출처
- J Med Chem.
- 등재일
- 2017 Jun 22
- 저널이슈번호
- 60(12):4861-4868. doi: 10.1021/acs.jmedchem.7b00060. Epub 2017 May 31.
- 내용
Abstract
We report the synthesis of a macrocyclic Gd chelate based on a 1,4,7,10-tetraazacyclododecane-1,4,7-trisacetic acid (DO3A) coordinationn cage bearing an ethoxybenzyl (EOB) moiety and discuss its use as a T1 hepatobiliary magnetic resonance imaging (MRI) contrast agent. The new macrocyclic liver agent shows high chelation stability and high r1 relaxivity compared with linear-type Gd chelates, which are the current clinically approved liver agents. Our macrocyclic, liver-specific Gd chelate was evaluated in vivo through biodistribution analysis and liver MRI, which demonstrated its high tumor detection sensitivity and suggested that the new Gd complex is a promising contrast agent for liver cancer imaging.
Author information
Baek AR, Kim HK, Park S, Lee GH, Kang HJ, Jung JC, Park JS1, Ryeom HK, Kim TJ, Chang Y.
1Laboratory Animal Center, Daegu-Gyeongbuk Medical Innovation Foundation Chumbok-ro 80, Dong-gu, Daegu 41061, Korea.
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