방사선의학 웹진

바로가기  >

Abstract

Recently, nanotechnology has provided significant advances in biomedical applications including diagnosis and therapy. In particular, nanoparticles have emerged as valuable outcomes of nanotechnology due to their unique physicochemical properties based on size, shape, and surface properties. Among them, a large amount of research has reported imaging and therapeutic applications using inorganic nanoparticles with special properties. Inorganic nanoparticles developed for imaging and therapy contain metal (Au), metal oxide (Fe3O4, WO3, WO2.9), semiconductor nanocrystal (quantum dots (QDs)), and lanthanide-doped upconversion nanoparticles (UCNPs). Based on their intrinsic properties, they can generate heat, reactive oxygen species (ROS), or energy transfer, so that they can be used for both imaging and therapy. In this review, we introduce biocompatible inorganic nanoparticles for image-guided thermal and photodynamic therapy, and discuss their promising results from in vitro and in vivo studies for biomedical applications.

Author information

Yoon HY1, Jeon S1,2, You DG1,2, Park JH2, Kwon IC1,3, Koo H4, Kim K1.​

1Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology , 5, Hwarang-ro 14-gil, Seongbuk-gu, Seoul 02792, Republic of Korea.

2School of Chemical Engineering, Sungkyunkwan University , 2066, Seobu-ro, Jangan-gu, Suwon 16419, Republic of Korea.

3KU-KIST Graduate School of Converging Science and Technology, Korea University , 145 Anam-ro, Seongbuk-gu, Seoul, 02841, Republic of Korea.

4Department of Medical Lifescience, College of Medicine, The Catholic University of Korea , 222 Banpo-daero, Seocho-gu, Seoul 06591, Republic of Korea.