방사선의학 웹진

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Lee JY1, Vyas CK2, Kim BR2, Kim HJ2, Hur MG2, Yang SD2, Park JH3, Kim SW4.

Author information

1Department of Advanced Materials Chemistry, College of Science and Technology, Dongguk University-Gyeongju, Gyeongbuk 780-714, Republic of Korea; Radiation Instrumentation Research Division, Korea Atomic Energy Research Institute, Jeongeup 580-185, Republic of Korea.

2Radiation Instrumentation Research Division, Korea Atomic Energy Research Institute, Jeongeup 580-185, Republic of Korea.

3Radiation Instrumentation Research Division, Korea Atomic Energy Research Institute, Jeongeup 580-185, Republic of Korea. Electronic address: parkjh@kaeri.re.kr.

4Department of Advanced Materials Chemistry, College of Science and Technology, Dongguk University-Gyeongju, Gyeongbuk 780-714, Republic of Korea. Electronic address: swkim@dongguk.ac.kr.

Abstract

The 68Ge/68Ga generator system is an excellent source for producing ready-to-use Ga-68 in clinical Positron Emission Tomography (PET) applications. The column adsorbent is the key component for the 68Ge/68Ga generator system. Therefore, several studies have been conducted to identify column materials with a stable and superior elution yield in an acidic eluent (0.1 N HCl solution). In this study, four different zirconium phosphates were synthesized with a particle size of 200-800nm, pore-size of 55∼190Å and surface area of 0.72-268m2g-1. Synthesized and studied amorphous zirconium phosphate (ZrP-1) exhibited excellent acid resistant properties for the 0.1 N HCl eluent and a large surface area of 268m2g-1. Amorphous ZrP-1 showed a good Ga-68 elution yield of 74% in 0.1 N HCl eluent accompanying extraordinary low breakthrough of Ge-68 (0.007%).​