방사선의학 웹진

바로가기  >

Abstract

Ionizing radiation (IR) injury is tissue damage caused by high energy electromagnetic waves such as X-ray and gamma ray. Diagnosis and treatment of IR injury are difficult due to its characteristics of clinically latent post-irradiation periods and the following successive and unpredictable inflammatory bursts. Skin is one of the many sensitive organs to IR and bears local injury upon exposure. Early-stage diagnosis of IR skin injury is essential in order to maximize treatment efficiency and to prevent the aggravation of IR injury. In this study, early-stage changes of the IR injured skin at the cellular level were characterized in an in vivo mouse model by two-photon microscopy (TPM). Various IR doses were applied to the mouse hind limbs and the injured skin regions were imaged daily for 6 days after IR irradiation. Changes in the morphology and distribution of the epidermal cells and damage of the sebaceous glands were observed before clinical symptoms. These results showed that TPM is sensitive to early-stage changes of IR skin injury and may be useful for its diagnosis. 

Author information

Jang WH1, Shim S2, Wang T1, Yoon Y3, Jang WS4, Myung JK2,4,5, Park S2,4,5, Kim KH1,3.​

1Divison of Integrative Biosciences &Biotechnology, Pohang University of Science and Technology, 77 Cheongam-Ro, Nam-gu, Pohang, Gyeongbuk 37673, Rep. of Korea.

2National Radiation Emergency Medical Centre, Korea Cancer Centre Hospital, Korea Institute of Radiological &Medical Sciences (KIRAMS), 75 Nowon-ro, Nowon-gu, Seoul 01812, Rep. of Korea.

3Department of Mechanical Engineering, Pohang University of Science and Technology, 77 Cheongam-Ro, Nam-gu, Pohang, Gyeongbuk 37673, Rep. of Korea.

4Laboratory of Experimental Pathology, Korea Cancer Centre Hospital, Korea Institute of Radiological &Medical Sciences (KIRAMS), 75 Nowon-ro, Nowon-gu, Seoul 01812, Rep. of Korea.

5Department of Pathology, Korea Cancer Centre Hospital, Korea Institute of Radiological &Medical Sciences (KIRAMS), 75 Nowon-ro, Nowon-gu, Seoul 01812, Rep. of Korea.