DIRAMS / 백지수, 김성대*
This study investigated the inhibitory effect of ginsenoside-Rp1 (G-Rp1) on the ionizing radiation (IR)-induced response in lipopolysaccharide (LPS)-stimulated macrophages and its effects on the malignancy of tumor cells. G-Rp1 inhibited the activation of IR-induced DNA damage-related signaling molecules and thereby interfered with the IR-increased production of nitric oxide (NO) and interleukin (IL)-1β. The inhibitory effect of G-Rp1 increased the survival rate of mice inoculated with CT26 colon cancer cells by suppressing the phenotypic variation of tumor cells induced by conditioned medium obtained from IR- and LPS-treated J774A.1 macrophages.
Ji Sue Baik 1 , You Na Seo 1 , Joo Mi Yi 2 , Man Hee Rhee 3 , Moon-Taek Park 1 , Sung Dae Kim 1
1 Research Center, Dongnam Institute of Radiological & Medical Sciences, Busan, Republic of Korea.
2 Department of Microbiology and Immunology, College of Medicine, Inje University, Busan, Republic of Korea.
3 Department of Veterinary Medicine, College of Veterinary Medicine, Kyungpook National University, Daegu, Republic of Korea.