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  • [J Ginseng Res.] Ginsenoside-Rp1 inhibits radiation-induced effects in lipopolysaccharide-stimulated J774A.1 macrophages and suppresses phenotypic variation in CT26 colon cancer cells

    DIRAMS / 백지수, 김성대*

  • 출처
    J Ginseng Res.
  • 등재일
    2020 Nov
  • 저널이슈번호
    44(6):843-848. doi: 10.1016/j.jgr.2020.01.006. Epub 2020 Jan 31.
  • 내용

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    Abstract
    This study investigated the inhibitory effect of ginsenoside-Rp1 (G-Rp1) on the ionizing radiation (IR)-induced response in lipopolysaccharide (LPS)-stimulated macrophages and its effects on the malignancy of tumor cells. G-Rp1 inhibited the activation of IR-induced DNA damage-related signaling molecules and thereby interfered with the IR-increased production of nitric oxide (NO) and interleukin (IL)-1β. The inhibitory effect of G-Rp1 increased the survival rate of mice inoculated with CT26 colon cancer cells by suppressing the phenotypic variation of tumor cells induced by conditioned medium obtained from IR- and LPS-treated J774A.1 macrophages.

     

     

    Affiliations

    Ji Sue Baik  1 , You Na Seo  1 , Joo Mi Yi  2 , Man Hee Rhee  3 , Moon-Taek Park  1 , Sung Dae Kim  1
    1 Research Center, Dongnam Institute of Radiological & Medical Sciences, Busan, Republic of Korea.
    2 Department of Microbiology and Immunology, College of Medicine, Inje University, Busan, Republic of Korea.
    3 Department of Veterinary Medicine, College of Veterinary Medicine, Kyungpook National University, Daegu, Republic of Korea.

  • 키워드
    Cancer; Ginsenoside-Rp1; Macrophages; Panax ginseng; Radiation.
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