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방사선생물학
- 2020년 02월호
[Int Immunopharmacol.] A hydroxyethyl derivative of chrysin exhibits anti-inflammatory activity in dendritic cells and protective effects against dextran sodium salt-induced colitis in mice.KAERI / 송하연, 변의백*
- 출처
- Int Immunopharmacol.
- 등재일
- 2019 Dec
- 저널이슈번호
- 77:105958. doi: 10.1016/j.intimp.2019.105958. Epub 2019 Oct 19.
- 내용
Abstract
Inflammatory bowel disease (IBD) is a chronic disease that occurs in the intestinal tract. Phyto-ingredients have been evaluated for their ability to protect against IBD because of their anti-inflammatory activities. In our previous study, we identified a novel derivative of chrysin (HE-chrysin) using irradiation technology, which exhibited stronger anti-cancer activity in human colorectal cancer cells than the original chrysin. Here, to determine whether HE-chrysin is a new therapeutic candidate for IBD, we investigated the anti-inflammatory effects of HE-chrysin on bone marrow-derived dendritic cells (BMDCs) and dextran sodium salt (DSS)-induced colitis in mice. HE-chrysin more effectively inhibited BMDC maturation compared to chrysin, as demonstrated by the decreased levels of pro-inflammatory cytokines, surface molecules, antigen-presenting ability, and T cell proliferation/activation in lipopolysaccharide-stimulated BMDCs. These anti-inflammatory effects of HE-chrysin were regulated by mitogen-activated protein kinases and nuclear factor-κB. Furthermore, oral administration of HE-chrysin attenuated DSS-induced colitis symptoms and clinical signs in the mouse model. The protective effects of HE-chrysin treatment against colitis were mediated by decreasing Th1- and Th17-type cytokine levels. These results indicate that HE-chrysin is attractive candidate for IBD therapy.
Author informationSong HY1, Sik Kim W2, Kim JM3, Bak DH2, Moo Han J1, Lim ST4, Byun EB5.
1
Department of Biotechnology, Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, Jeongeup 56212, Republic of Korea; Department of Biotechnology, College of Life science and Biotechnology, Korea University, Seoul 02841, Republic of Korea.
2
Department of Biotechnology, Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, Jeongeup 56212, Republic of Korea.
3
Department of Pathology, College of Medicine, Chungnam National University, Daejeon 301-747, Republic of Korea.
4
Department of Biotechnology, College of Life science and Biotechnology, Korea University, Seoul 02841, Republic of Korea.
5
Department of Biotechnology, Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, Jeongeup 56212, Republic of Korea. Electronic address: ebbyun80@kaeri.re.kr.
- 키워드
- Anti-inflammation; Chrysin derivative; DSS-induced colitis; Dendritic cells; Flavonoids; Inflammatory bowel disease
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