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Abstract
Purpose: The purpose of this study is to propose a technique for delivering accurate doses in an image-guided system by developing an experimental setup optimized for total lymphoid irradiation (TLI) in rat lung transplantation.

Materials and methods: In this study, a position-controlled shielding system was developed, and the dose was quantitatively evaluated using a 3D rat phantom and Gafchromic EBT3 film. In addition, we made our own image-guided system that allows the position of the rat and the shielding system to be confirmed during TLI.

Results: As a result of using the position-controlled shielding system, it was found that the doses to the head and lungs were reduced by 93.1 and 87.4%, respectively, of the prescribed doses. In addition, it was shown that the position of the shielding system can be easily confirmed by using the image guidance system.

Conclusion: A shielding apparatus that can control dose delivery according to the size of the rat can optimize the dose for TLI in rat lung transplantation.

Affiliations

Dong Hyeok Choi  1 , So Hyun Ahn  2 , Kwangwoo Park  3 , Sang Hyun Choi  4 , Jin Sung Kim  1   2
1 Department of Medicine, Yonsei University College of Medicine, Seoul, South Korea.
2 Department of Radiation Oncology, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, South Korea.
3 Department of Radiation Oncology, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, South Korea.
4 Research Team of Radiological Physics and Engineering, Korea Institute of Radiological and Medical Sciences, Seoul, South Korea.