연세의대 / 이준복, 이익제, *이호
Abstract
With the introduction of modern sophisticated radiotherapy (RT) techniques, the significance of accuracy has increased considerably. This study evaluated the necessity of pre-treatment and intra-fractional cone-beam computed tomography (CBCT) by analyzing inter- and intra-fractional CBCT images of breast cancer patients receiving RT. From 57 patients, 1206 pre-treatment CBCT and 1067 intra-fractional CBCT images were collected. Geometric movements of patients were measured quantitively in both inter- and intra-fractional CBCT, and changes in dosimetric parameters were evaluated in selected patients with extreme intra-fractional movement. For right-sided breast cancer patients, left-sided breast cancer patients treated using deep-inspiration breath hold (DIBH), and left-sided breast cancer patients treated using continuous positive airway pressure (CPAP), median inter-fractional deviations were 0.53 (range 0.06-2.98) cm, 0.66 (range 0.08-4.41) cm, and 0.69 (range 0.04-3.80) cm, and median intra-fractional deviations were 0.14 (range 0.00-0.62) cm, 0.23 (range 0.02-0.96) cm, and 0.24 (0.00-1.15) cm, respectively. Modified plans reflecting large changes in intra-fractional position in 10 selected cases revealed insufficient target coverage in seven cases and more than 20-fold increase in the volume of heart receiving at least 25 Gy in two cases. Intra-fractional verification, as well as pre-treatment verification, might be considered in patients using DIBH or CPAP.
Affiliations
Jason Joon Bock Lee 1 2 , Ik Jae Lee 1 , Yeonho Choi 1 , Mi Jin Jeon 1 , Il Hun Jung 1 , Ho Lee 1
1 Department of Radiation Oncology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul 06273, Korea.
2 Department of Radiation Oncology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul 03181, Korea.
편집위원
본 연구는 유방암 환자에 대한 방사선치료 시 폐 및 심장 등 주변 장기에 들어가는 선량을 최소화하기 위하여 DIBH 및 CPAP 등을 사용할 때 발생하는 intra-fractional motion을 평가하였음. 일렉타 선형가속기의 intra-fractional CBCT를 촬영한 결과, 심한 경우 1.15 cm까지 움직임이 발생하며 이로 인해 PTV의 D95%가 치료 허용 수준 이하로 감소하는 것을 확인하였음. 따라서 예상치 못한 intra-fractional motion을 방지하기 위해서는 치료 중 CBCT 촬영을 적극 활용하는 것이 권장됨을 정량적으로 보여준 의미 있는 연구 성과임.
2021-06-07 11:42:18