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  • [Oncotarget.] Correlation analysis between 2D and quasi-3D gamma evaluations for both intensity-modulated radiation therapy and volumetric modulated arc therapy.

    [Oncotarget.] Correlation analysis between 2D and quasi-3D gamma evaluations for both intensity-modulated radiation therapy and volumetric modulated arc therapy.

    서울의대 / 김정인, 최창헌, 우홍균, 김진호, 박종민*

  • 출처
    Oncotarget.
  • 등재일
    2017 Jan 17
  • 저널이슈번호
    8(3):5449-5459. doi: 10.18632/oncotarget.12279.
  • 내용

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    Abstract

    The aim of this work was to investigate correlations between 2D and quasi-3D gamma passing rates. A total of 20 patients (10 prostate cases and 10 head and neck cases, H&N) were retrospectively selected. For each patient, both intensity-modulated radiation therapy (IMRT) and volumetric modulated arc therapy (VMAT) plans were generated. For each plan, 2D gamma evaluation with radiochromic films and quasi-3D gamma evaluation with fluence measurements were performed with both 2%/2 mm and 3%/3 mm criteria. Gamma passing rates were grouped together according to delivery techniques and treatment sites. Statistical analyses were performed to examine the correlation between 2D and quasi-3D gamma evaluations. Statistically significant difference was observed between delivery techniques only in the quasi-3D gamma passing rates with 2%/2 mm. Statistically significant differences were observed between treatment sites in the 2D gamma passing rates (differences of less than 8%). No statistically significant correlations were observed between 2D and quasi-3D gamma passing rates except the VMAT group and the group including both IMRT and VMAT with 3%/3 mm (r = 0.564 with p = 0.012 for theVMAT group and r = 0.372 with p = 0.020 for the group including both IMRT and VMAT), however, those were not strong. No strong correlations were observed between 2D and quasi-3D gamma evaluations.

     

    Kim JIAuthor information

    Kim JI1,2,3, Choi CH1,2,3,4, Wu HG1,2,3,5, Kim JH1,2,3, Kim K6, Park JM1,2,3,4.

    Department of Radiation Oncology, Seoul National University Hospital, Seoul, Republic of Korea.

    Institute of Radiation Medicine, Seoul National University Medical Research Center, Seoul, Republic of Korea.

    Biomedical Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea.

    Center for Convergence Research on Robotics, Advanced Institutes of Convergence Technology, Suwon, Republic of Korea.

    Department of Radiation Oncology, Seoul National University College of Medicine, Seoul, Republic of Korea.

    Department of Radiation Oncology, Ewha Womans University School of Medicine, Seoul, Republic of Korea. 

  • 키워드
    2D gamma evaluation; intensity-modulated radiation therapy; pre-treatment patient-specific quality assurance; quasi-3D gamma evaluation; volumetric modulated arc therapy​
  • 연구소개
    임상에서 IMRT/VMAT 환자특이적 정도관리를 위해 널리 사용되고 있는 2D 감마분석법의 성능평가를 위해, VMAT 치료계획을 대상으로 2D 감마분석결과와 quasi-3D 감마분석결과의 상관관계를 연구한 논문입니다. 분석 결과, 2D 감마분석결과와 quasi-3D 감마분석결과 사이에 유의한 상관관계가 없음을 확인했습니다. 이는 더욱 많은 정보를 가지고 있는 quasi-3D 감마분석에 비해, 2D 감마분석이 정보량이 부족했기 때문으로 생각됩니다. 따라서, 임상에서 보다 정밀하고 민감한 환자특이적 정도관리를 수행하기 위하여 quasi-3D 감마분석법을 사용하는 것이 권고됩니다.
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