서울의대 / 신동주, 김수연*
Abstract
We investigated the correlation between standardized uptake value (SUV) of 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) and conductivity parameters in breast cancer and explored the feasibility of conductivity as an imaging biomarker. Both SUV and conductivity have the potential to reflect the tumors' heterogeneous characteristics, but their correlations have not been investigated until now. Forty four women diagnosed with breast cancer who underwent breast MRI and 18F-FDG PET/CT at the time of diagnosis were included. Among them, 17 women received neoadjuvant chemotherapy followed by surgery and 27 women underwent upfront surgery. For conductivity parameters, maximum and mean values of the tumor region-of-interests were examined. For SUV parameters, SUVmax, SUVmean, and SUVpeak of the tumor region-of-interests were examined. Correlations between conductivity and SUV were evaluated, and among them, the highest correlation was observed between mean conductivity and SUVpeak (Spearman's correlation coefficient = 0.381). In a subgroup analysis for 27 women with upfront surgery, tumors with lymphovascular invasion (LVI) showed higher mean conductivity than those without LVI (median: 0.49 S/m vs 0.06 S/m, p < 0.001). In conclusion, our study shows a low positive correlation between SUVpeak and mean conductivity in breast cancer. Furthermore, conductivity showed a potential to noninvasively predict LVI status.
Affiliations
Dong-Joo Shin 1 2 3, Hongyoon Choi 4, Dong Kyu Oh 4, Hyun Pil Sung 4, Jun-Hyeong Kim 5, Dong-Hyun Kim 5, Soo-Yeon Kim 6 7 8
1Department of Radiology, Seoul National University Hospital, Seoul, Republic of Korea.
2Department of Radiology, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, 110-744, Republic of Korea.
3Institute of Radiation Medicine, Seoul National University Medical Research Center, Seoul, Republic of Korea.
4Department of Nuclear Medicine, Seoul National University Hospital, Seoul, Republic of Korea.
5Department of Electrical and Electronic Engineering, Yonsei University, Seoul, Republic of Korea.
6Department of Radiology, Seoul National University Hospital, Seoul, Republic of Korea. sooyeonkim41@gmail.com.
7Department of Radiology, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, 110-744, Republic of Korea. sooyeonkim41@gmail.com.
8Institute of Radiation Medicine, Seoul National University Medical Research Center, Seoul, Republic of Korea. sooyeonkim41@gmail.com.