바로가기  >

Abstract
Aims: The aim of this study was to investigate the associations of enlarged perivascular spaces (EPVS) in the basal ganglia (BG) and centrum semiovale (CSO) with beta-amyloid (Aβ) and tau deposition in older adults with a diverse cognitive spectrum.

Methods: A total of 163 (68 cognitively normal and 95 cognitively impaired) older participants underwent [11 C] Pittsburgh compound B and [18 F] AV-1451 PET, and MRI. EPVS in the BG and CSO and other small vessel disease markers, such as white matter hyperintensities, lacunes, and deep and lobar microbleeds, were assessed.

Results: Increased EPVS in the BG showed a significant association with lower cerebral tau deposition, even after controlling for other small vessel disease markers. Further exploratory analyses showed that this association was significant in cognitively impaired, Aβ-positive, or APOE4-positive individuals, but not significant in the cognitively normal, Aβ-negative, or APOE4-negative participants. In contrast to EPVS in the BG, EPVS in the CSO did not have any relationship with cerebral tau deposition. In addition, none of the two types of EPVS were associated with cerebral Aβ deposition.

Conclusion: Brain tau deposition appears to be reduced with increased EPVS in the BG, especially in individuals with cognitive impairment, pathological amyloid burden, or genetic Alzheimer's disease risk

Affiliations

Koung Mi Kang 1 2, Min Soo Byun 3 4, Dahyun Yi 5, Kyung Hoon Lee 1, Min Jung Kim 4, Hyejin Ahn 4, Gijung Jung 4, Jun-Young Lee 3 6, Yu Kyeong Kim 7, Yun-Sang Lee 8, Chul-Ho Sohn 1 2, Dong Young Lee 3 4 9; KBASE Research Group
1Department of Radiology, Seoul National University Hospital, Seoul, Korea.
2Department of Radiology, Seoul National University College of Medicine, Seoul, Korea.
3Department of Neuropsychiatry, Seoul National University College of Medicine, Seoul, Korea.
4Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Korea.
5Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea.
6Department of Neuropsychiatry, SMG-SNU Boramae Medical Center, Seoul, Korea.
7Department of Nuclear Medicine, SMG-SNU Boramae Medical Center, Seoul, Korea.
8Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Korea.
9Institute of Human Behavioral Medicine, Medical Research Center Seoul National University, Seoul, Korea.