방사선의학 웹진

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Abstract

AIMS:

The present study was aimed to investigate whether volumetric parameters measured by sequential F-18 fluoro-D-glucose (F-18 FDG) positron emission tomography/computed tomography (PET/CT) could be used as prognostic factors in patients with locally advanced esophageal cancer (LAEC) who received preoperative chemoradiotherapy (CRT).

METHODS:

A total of 61 patients with LAEC were included in the current study. All patients were evaluated by F-18 FDG PET/CT before and after 46 Gy of radiotherapy with a concurrent cisplatin-based chemotherapy. Initial, second, and percent changes (x0394;, %) of semiquantitative and volumetric parameters were used to calculate recurrence-free survival (RFS) and overall survival (OS). The median values of each parameter were used as cutoff values. The prognostic significance was assessed using univariate and multivariate Cox proportional hazard regression analyses.

RESULTS:

Cox proportional hazard regression analyses revealed that change in total lesion glycolysis (x0394;TLG) was a potent predictor of RFS and OS. Kaplan-Meier survival curves showed better prognosis in higher x0394;TLG.

CONCLUSION:

Our data suggest that x0394;TLG measured by sequential F-18 FDG PET/CT after preoperative CRT could provide prognostic information in LAEC patients. 

Author information

Chang S1, Koo PJ, Kwak JJ, Kim SJ.​

1Department of Radiology, University of Colorado School of Medicine, Aurora, Colo., USA.