글로벌 연구동향
핵의학
- 2016년 02월호
[J Nucl Med] Exploratory Clinical Investigation of (4S)-4-(3-18F-Fluoropropyl)-l-Glutamate PET of Inflammatory and Infectious Lesions.울산의대/ 채선영, 문대혁*
- 출처
- J Nucl Med
- 등재일
- 2016 Jan
- 저널이슈번호
- 57(1):67-9. doi: 10.2967/jnumed.115.164020. Epub 2015 Oct 15.
- 내용
Abstract
We explored system [Formula: see text] transporter activity and the detection of inflammatory or infectious lesions using (4S)-4-(3-(18)F-fluoropropyl)-l-glutamate ((18)F-FSPG) PET.
METHODS:
In 10 patients with various inflammatory or infectious diseases, as many as 5 of the largest lesions were selected as reference lesions. (18)F-FSPG images were assessed visually and quantitatively. Expression levels of xCT, CD44, and surface markers of inflammatory cells were evaluated by immunohistochemistry.
RESULTS:
(18)F-FSPG PET detected all reference lesions. (18)F-FSPG uptake in sarcoidosis was significantly higher than that in nonsarcoidosis. The lesion-to-blood-pool SUV ratio for (18)F-FSPG was comparable to that for (18)F-FDG in sarcoidosis. In nonsarcoidosis, however, it was significantly lower. In 5 patients with available tissue samples, the SUVmax for (18)F-FSPG and CD163 were negatively correlated (ρ = -0.872, P = 0.054).
CONCLUSION:
(18)F-FSPG PET may detect inflammatory lesions when activated macrophages or monocytes are present, such as in sarcoidosis.
Author information
Chae SY1, Choi CM2, Shim TS2, Park Y3, Park CS3, Lee HS1, Lee SJ1, Oh SJ1, Kim SY4, Baek S5, Koglin N6, Stephens AW6, Dinkelborg LM6, Moon DH7.
1Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
2Department of Pulmonology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
3Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
4Institute for Innovative Cancer Research, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
5Department of Nuclear Medicine, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Republic of Korea; and.
6Piramal Imaging, Berlin, Germany.
7Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea dhmoon@amc.seoul.kr.
- 키워드
- glutamate; infection; inflammation; positron emission tomography; xC− transporter
- 덧글달기
- 이전글 [Oncol Res Treat.] Tumor Heterogeneity Assessed by 18F-FDG PET/CT Is Not Significantly Associated with Nodal Metastasis in Breast Cancer Patients.
- 다음글 [J Nucl Med] Troglitazone Stimulates Cancer Cell Uptake of 18F-FDG by Suppressing Mitochondrial Respiration and Augments Sensitivity to Glucose Restriction.
