방사선의학 웹진

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Abstract
Invasive aspergillosis is a critical complication in immunocompromised patients with hematologic malignancies or with viral pneumonia caused by influenza virus or SARS‑CoV‑2. Although early and accurate diagnosis of invasive aspergillosis can maximize clinical outcomes, current diagnostic methods are time-consuming and poorly sensitive. Here, we assess the ability of 2-deoxy-2-18F-fluorosorbitol (18F-FDS) positron emission tomography (PET) to specifically and noninvasively detect Aspergillus infections. We show that 18F-FDS PET can be used to visualize Aspergillus fumigatus infection of the lungs, brain, and muscles in mouse models. In particular, 18F-FDS can distinguish pulmonary aspergillosis from Staphylococcus aureus infection, both of which induce pulmonary infiltrates in immunocompromised patients. Thus, our results indicate that the combination of 18F-FDS PET and appropriate clinical information may be useful in the differential diagnosis and localization of invasive aspergillosis.

Affiliations

Dong-Yeon Kim #  1   2 , Ayoung Pyo #  3   4 , Sehyeon Ji  5 , Sung-Hwan You  2   6 , Seong Eun Kim  5 , Daejin Lim  7 , Heejung Kim  8 , Kyung-Hwa Lee  9 , Se-Jeong Oh  10 , Ye-Rim Jung  3   6 , Uh Jin Kim  5 , Subin Jeon  3 , Seong Young Kwon  3   6 , Sae-Ryung Kang  3   6 , Hyang Burm Lee  11 , Hoon Hyun  12 , So-Young Kim  2   6 , Kyung-Sub Moon  10 , Sunwoo Lee  13 , Seung Ji Kang  14 , Jung-Joon Min  15   16   17
1 College of Pharmacy and Research Institute of Pharmaceutical Science, Gyeongsang National University, Jinju, Korea.
2 CNCure Biotech, Hwasun, Korea.
3 Innovation Center for Molecular Probe Development, Department of Nuclear Medicine, Chonnam National University Medical School and Hwasun Hospital, Hwasun, Korea.
4 Accelerator & RI Development Team, Korea Atomic Energy Research Institute, Jeongeup, Korea.
5 Department of Internal Medicine, Chonnam National University Medical School, Hwasun, Korea.
6 Institute for Molecular Imaging and Theranostics, Chonnam National University Medical School, Hwasun, Korea.
7 Division of Biomedical Convergence, College of Biomedical Science, Kangwon National University, Chuncheon, Korea.
8 Korea Radioisotope Center for Pharmaceuticals, Korea Institute of Radiological & Medical Sciences, Seoul, Korea.
9 Department of Pathology, Chonnam National University Medical School, Hwasun, Korea.
10 Department of Neurosurgery, Chonnam National University Medical School, Hwasun, Korea.
11 Department of Agricultural Biological Chemistry, Chonnam National University, Gwangju, Korea.
12 Department of Biomedical Sciences, Chonnam National University Medical School, Hwasun, Korea.
13 Department of Chemistry, Chonnam National University, Gwangju, Korea.
14 Department of Internal Medicine, Chonnam National University Medical School, Hwasun, Korea. sseungi@gmail.com.
15 CNCure Biotech, Hwasun, Korea. jjmin@jnu.ac.kr.
16 Innovation Center for Molecular Probe Development, Department of Nuclear Medicine, Chonnam National University Medical School and Hwasun Hospital, Hwasun, Korea. jjmin@jnu.ac.kr.
17 Institute for Molecular Imaging and Theranostics, Chonnam National University Medical School, Hwasun, Korea. jjmin@jnu.ac.kr.
# Contributed equally.