글로벌 연구동향
핵의학
- 2022년 06월호
[J Pers Med.] Prognostic Value of Dual-Time-Point [ 18 F]FDG PET/CT for Predicting Distant Metastasis after Treatment in Patients with Non-Small Cell Lung Cancer차의과대 / 이상미, 이정원, 장수진*
- 출처
- J Pers Med.
- 등재일
- 2022 Apr 7
- 저널이슈번호
- 12(4):592. doi: 10.3390/jpm12040592.
- 내용
Abstract
This study aimed to evaluate the prognostic significance of 2-Deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) uptake in the bone marrow (BM) and primary tumors on dual-time-point (DTP) PET/CT for predicting progression-free survival (PFS) and distant metastasis-free survival (DMFS) in patients with non-small cell lung cancer (NSCLC). We retrospectively analyzed DTP [18F]FDG PET/CT images from 211 patients with NSCLC. The maximum standardized uptake value (SUV) of primary lung cancer and mean [18F]FDG uptake of the BM (BM SUV) were measured from early and delayed PET/CT images, and the percent changes in these parameters (∆maximum SUV and ∆BM SUV) were calculated. On multivariate survival analysis, the maximum SUV and BM SUV on both early and delayed PET/CT scans were significantly associated with PFS, while the ∆maximum SUV and ∆BM SUV failed to show statistical significance. For DMFS, the ∆maximum SUV and ∆BM SUV were independent predictors along with the TNM stage. Distant progression was observed only in 1.3% of patients with low ∆maximum SUV and ∆BM SUV, whereas 28.2% of patients with high ∆maximum SUV and ∆BM SUV experienced distant progression. The ∆maximum SUV and ∆BM SUV on DTP [18F]FDG PET/CT were significant independent predictors for DMFS in patients with NSCLC.Affiliations
Sang Mi Lee 1 , Jeong Won Lee 2 , Ji-Hyun Lee 3 , In Young Jo 4 , Su Jin Jang 5
1 Department of Nuclear Medicine, Soonchunhyang University Cheonan Hospital, Cheonan 31151, Korea.
2 Department of Nuclear Medicine, International St. Mary's Hospital, Catholic Kwandong University, Incheon 22711, Korea.
3 Department of Pulmonology, Allergy and Critical Care Medicine, CHA Bundang Medical Center, Seongnam 13496, Korea.
4 Department of Radiation Oncology, Soonchunhyang University Cheonan Hospital, Cheonan 31151, Korea.
5 Department of Nuclear Medicine, CHA Bundang Medical Center, CHA University, Seongnam 13496, Korea.
- 키워드
- bone marrow; fluorodeoxyglucose F-18; non-small cell lung cancer; positron emission tomography; prognosis.
- 덧글달기
- 이전글 [Cancers (Basel).] Predictive Value of 18 F-FDG PET/CT Using Machine Learning for Pathological Response to Neoadjuvant Concurrent Chemoradiotherapy in Patients with Stage III Non-Small Cell Lung Cancer
- 다음글 [Endocrinol Metab (Seoul).] Transarterial Radioembolization as an Effective Local Treatment Modality for Liver Metastasis of Thyroid Cancer
편집위원
비소세포폐암 환자를 대상으로 18F-FDG PET/CT를 두차례 얻어 종양과와 골수의 FDG섭취를 이용 해당 종양의 예후를 예측하는 임상연구임. 해당 연구의 결과는 폐암관련 임상가 및 핵의학의사에게 관심을 끌 연구로 생각되며, FDG PET의 임상적 용도를 넓히는데 도움이 될 것으로 생각됨.
덧글달기닫기2022-06-08 14:53:36
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