계명대 / 김신, 김해원*
The visceral adipose tissue (VAT) has been recognized as an endocrine organ, and VAT dysfunction could be a risk factor for Alzheimer's disease (AD). We aimed to evaluate the association of VAT metabolism with AD pathology. This cross-sectional study included 54 older subjects with cognitive impairment who underwent 2-deoxy-2-[fluorine-18]-fluoro-D-glucose (18F-FDG) torso positron emission tomography (PET) and 18F-florbetaben brain PET. 18F-FDG uptake in VAT on 18F-FDG PET images was used as a marker of VAT metabolism, and subjects were classified into high and low VAT metabolism groups. A voxel-based analysis revealed that the high VAT metabolism group exhibited a significantly higher cerebral amyloid-β (Aβ) burden than the low VAT metabolism group. In the volume-of-interest analysis, multiple linear regression analyses with adjustment for age, sex, and white matter hyperintensity volume revealed that 18F-FDG uptake in VAT was significantly associated with the cerebral Aβ burden (β = 0.359, p = 0.007). In conclusion, VAT metabolism was associated with AD pathology in older subjects. Our findings suggest that VAT dysfunction could contribute to AD development.
Shin Kim 1 , Hyon-Ah Yi 2 , Kyoung Sook Won 3 , Ji Soo Lee 3 , Hae Won Kim 3
1 Department of Immunology, School of Medicine, Keimyung University, Daegu 42601, Korea.
2 Department of Neurology, Dongsan Hospital, Keimyung University, Daegu 42601, Korea.
3 Department of Nuclear Medicine, Dongsan Hospital, Keimyung University, Daegu 42601, Korea.
18F-FDG PET으로 얻어진 visceral adipose tissue의 FDG uptake 와 뇌조직의 아밀로이드 집적에 상관관계가 있음을 확인함. 해당 연구의 결과는 visceral adipose tissue의 포도당대사가 Alzheimer병 발병과 관련이 있을 수 있음을 추정하게 연구결과임. Alzheimer 치매관련 연구자 및 대사질환에 관심이 있는 임상가와 연구자에게 중요한 정보를 제공할 수 있는 연구로 생각됨.