글로벌 연구동향
핵의학
- 2016년 01월호
[Endocrine] Predictive value of intratumoral heterogeneity of F-18 FDG uptake for characterization of thyroid nodules according to Bethesda categories of fine needle aspiration biopsy results.부산의대 / 김성장*
- 출처
- Endocrine
- 등재일
- 2015 Dec
- 저널이슈번호
- 50(3):681-8. doi: 10.1007/s12020-015-0620-z. Epub 2015 May 7.
- 내용
Abstract
The current study was aimed to investigate the clinical value of intratumoral heterogeneity of F-18 FDG uptake for characterization of thyroid nodule (TN) with inconclusive fine-needle aspiration biopsy (FNAB) results. The current study enrolled 200 patients who showed F-18 FDG incidentaloma and were performed FNAB. The intratumoral heterogeneity of F-18 FDG uptake was represented as the heterogeneity factor (HF), defined as the derivative (dV/dT) of a volume-threshold function for a primary tumor. The diagnostic and predictive values of HF and F-18 FDG PET/CT parameters were evaluated for characterization of inconclusive FNAB results. Among F-18 FDG PET/CT parameters, SUVmax, MTV, and TLG of malignant group were statistically higher than those of Bethesda category of suspicious malignant group. However, HF values were not statistically different between the groups of Bethesda categories (Kruskal-Wallis statistics, 9.924; p = 0.0774). In ROC analysis, when HF > 2.751 was used as cut-off value, the sensitivity and specificity for prediction of malignant TN were 100 % (95 % CI 69.2-100 %) and 60 % (95 % CI 42.1-76.1 %), respectively. The AUC was 0.826 (95 % CI 0.684-0.922) and standard error was 0.0648 (p < 0.0001). In conclusion, the intratumoral heterogeneity of F-18 FDG uptake represented by HF could be a predictor for characterization of TN with inconclusive FNAB results. Additional large population-based prospective studies are needed to validate the diagnostic utility of HF of F-18 FDG PET/CT.
Author information
Kim SJ1,2, Chang S3.
1 Department of Nuclear Medicine, Pusan National University Hospital, 179 Gudeok-Ro, Seo-Gu, Busan, 602-739, Republic of Korea. growthkim@daum.net.
2 Biomedical Research Institute, Pusan National University Hospital, Busan, 602-739, Republic of Korea. growthkim@daum.net.
3 Department of Radiology, University of Colorado School of Medicine, 12401, 17th Ave, Aurora, CO, 80045, USA.
- 키워드
- F-18 FDG PET/CT; FNAB; Inconclusive; Thyroid nodule
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