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Abstract
68Ga-NOTA Glu-Urea-Lys (NGUL) is a novel prostate-specific membrane antigen (PSMA)-targeting tracer used for PET/CT imaging. This study aimed to compare performance in the detection of primary and metastatic lesions and to compare biodistribution between 68Ga-NGUL and 68Ga-PSMA-11 in the same patients with prostate cancer. Methods: Eleven patients with metastatic prostate cancer were prospectively recruited. The quantitative tracer uptake was determined in normal organs and in primary and metastatic lesions. Results: 68Ga-NGUL showed significantly lower normal-organ uptake and rapid urinary clearance. The number and sites of detected PSMA-positive primary and metastatic lesions were identical, and no significant quantitative uptake difference was observed. 68Ga-NGUL showed a relatively lower tumor-to-background ratio than 68Ga-PSMA-11. Conclusion: In a head-to-head comparison with 68Ga-PSMA-11, 68Ga-NGUL showed lower uptake in normal organs and similar performance in detecting PSMA-avid primary and metastatic lesions. 68Ga-NGUL could be a valuable option for PSMA imaging.

Affiliations

Minseok Suh  1   2 , Hyung-Jun Im  2   3 , Hyun Gee Ryoo  1   2 , Keon Wook Kang  1 , Jae Min Jeong  1 , Sneha Prakash  4 , Sanjana Ballal  4 , Madhav P Yadav  4 , Chandrasekhar Bal  4 , Chang Wook Jeong  5 , Cheol Kwak  5 , Gi Jeong Cheon  6   7   8
1 Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Korea.
2 Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Korea.
3 Department of Applied Bioengineering, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Korea.
4 Department of Nuclear Medicine, AIIMS, New Delhi, India.
5 Department of Urology, Seoul National University College of Medicine, Seoul, Korea.
6 Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Korea; larrycheon@gmail.com.
7 Cancer Research Institute, Seoul National University, Seoul Korea; and.
8 Institute of Radiation Medicine, College of Medicine, Seoul National University, Seoul, Korea.