방사선의학 웹진

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Abstract
Hair loss is a prevalent medical condition affecting both genders. In this study, we investigate the effects of a specific class of extracellular vesicles (EVs), namely human normal fibroblast-derived EVs (hFB-EVs), on human dermal papilla (DP) and outer root sheath (ORS) cells and examine the molecular mechanisms responsible for hair growth in hair follicles (HFs). We find that Wnt3a, which maintains the hair-generating activity of DP cells, is enriched and more strongly associated with hFB-EVs than with fibroblasts. Furthermore, hFB-EV-associated Wnt3a mediated receptor activation in cultured DP cells, leading to an increase in β-catenin in the cytoplasm and its translocation into the nucleus, thereby elevating expression of the target genes Axin2 and Lef1. Additionally, hFB-EVs promoted the migration, proliferation, and differentiation of ORS cells and elongation of the hair shaft in human HFs. These findings revealed a novel mechanism by which hFB-EVs influence hair growth.

Affiliations

Ramya Lakshmi Rajendran  1 , Prakash Gangadaran  1   2 , Mi Hee Kwack  2   3 , Ji Min Oh  1 , Chae Moon Hong  4 , Young Kwan Sung  2   3 , Jaetae Lee  1   4 , Byeong-Cheol Ahn  1   2   4
1 Department of Nuclear Medicine, School of Medicine, Kyungpook National University, Daegu, Korea.
2 BK21 FOUR KNU Convergence Educational Program of Biomedical Sciences for Creative Future Talents, School of Medicine, Kyungpook National University, Daegu, Korea.
3 Department of Immunology, School of Medicine, Kyungpook National University, Daegu, Korea.
4 Department of Nuclear Medicine, Kyungpook National University Hospital, Daegu, Korea.