글로벌 연구동향
핵의학
- 2020년 12월호
[J Pers Med.] Prognostic Value of CT-Attenuation and 18 F-Fluorodeoxyglucose Uptake of Periprostatic Adipose Tissue in Patients with Prostate Cancer순천향대병원 / 이정원, 이상미*
- 출처
- J Pers Med.
- 등재일
- 2020 Oct 22
- 저널이슈번호
- 10(4):E185. doi: 10.3390/jpm10040185.
- 내용
Abstract
This study aimed to assess the prognostic value of computed tomography (CT)-attenuation and 18F-fluorodeoxyglucose (FDG) uptake of periprostatic adipose tissue (PPAT) for predicting disease progression-free survival (DPFS) in patients with prostate cancer. Seventy-seven patients with prostate cancer who underwent staging FDG positron emission tomography (PET)/CT were retrospectively reviewed. CT-attenuation (HU) and FDG uptake (SUV) of PPAT were measured from the PET/CT images. The relationships between these PPAT parameters and clinical factors were assessed, and a Cox proportional hazard regression test was performed to evaluate the prognostic significance of PPAT HU and SUV. PPAT HU and SUV showed significant positive correlations with tumor stage and serum prostate-specific antigen level (PSA) (p < 0.05). Patients with high PPAT HU and SUV had significantly worse DPFS than those with low PPAT HU and SUV (p < 0.05). In multivariate analysis, PPAT SUV was a significant predictor of DPFS after adjusting for tumor stage, serum PSA, and tumor SUV (p = 0.003; hazard ratio, 1.50; 95% confidence interval, 1.15-1.96). CT-attenuation and FDG uptake of PPAT showed significant association with disease progression in patients with prostate cancer. These imaging findings may be evidence of the role of PPAT in prostate cancer progression.Affiliations
Jeong Won Lee 1 , Youn Soo Jeon 2 , Ki Hong Kim 2 , Hee Jo Yang 2 , Chang Ho Lee 2 , Sang Mi Lee 3
1 Department of Nuclear Medicine, Catholic Kwandong University College of Medicine, International St. Mary's Hospital, 25, Simgok-ro 100 beon-gil, Seo-gu, Incheon 22711, Korea.
2 Department of Urology, Soonchunhyang University Cheonan Hospital, 31, Suncheonhyang 6-gil, Dongnam-gu, Cheonan, Chungcheongnam-do 31151, Korea.
3 Department of Nuclear Medicine, Soonchunhyang University Cheonan Hospital, 31 Suncheonhyang 6-gil, Dongnam-gu, Cheonan, Chungcheongnam-do 31151, Korea.
- 키워드
- fluorodeoxyglucose F18; periprostatic adipose tissue; positron emission tomography; prognosis; prostate cancer.
- 덧글달기
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