글로벌 연구동향
핵의학
- 2019년 10월호
[Clin Nucl Med.] The Preventive Effect of Parotid Gland Massage on Salivary Gland Dysfunction During High-Dose Radioactive Iodine Therapy for Differentiated Thyroid Cancer: A Randomized Clinical Trial.경북의대 / 손승현, 안병철*
- 출처
- Clin Nucl Med.
- 등재일
- 2019 Aug
- 저널이슈번호
- 44(8):625-633. doi: 10.1097/RLU.0000000000002602.
- 내용
Abstract
PURPOSE:
To evaluate the preventive effect of parotid gland (PG) massage for PG damage during the I therapy, we prospectively investigated the serum amylase value and salivary gland scintigraphy (SGS) after I therapy.MATERIALS AND METHODS:
One hundred patients with thyroidectomized differentiated thyroid cancer who underwent high-dose I therapy were enrolled in the clinical trial and randomized into 2 groups (PG massage group and nonmassage group). The serum amylase value was obtained before and 24 hours after I therapy, and the SGSs were also taken just before and at 8 months after the I therapy. Change in serum amylase value and SGS was compared between PG massage and nonmassage groups.RESULTS:
The difference value of serum amylase was significantly lower in PG massage group than in nonmassage group (P = 0.0052). Worsening of PG function on SGS was observed in 43 (45.3%) of the 95 patients. The incidence rate of PG abnormality on F/U SGS was significantly lower in PG massage group than in nonmassage group (odds ratio, 0.3704; P = 0.0195). In the multiple regression analysis, PG massage significantly affected the abnormality on the 8-month F/U SGS (rpartial = -0.2741, P = 0.0090) after adjusting for clinical variables (age, sex, TNM stage, TSH preparation methods for the I therapy, and I dose).CONCLUSIONS:
PG gland massage significantly reduced the incidence rates of salivary gland dysfunction on the 8-month F/U SGS and the level of the serological marker of salivary gland destruction after I therapy. Therefore, PG gland massage could alleviate salivary gland damage related to I therapy.그림. 갑상선스캔 상 마사지를 시행한 군에서 이하선의 손상빈도가 낮게 발생함을 보여준 그래프임.
Author informationSon SH1,2, Lee CH1,2, Jung JH1,2, Kim DH1,2, Hong CM1,2, Jeong JH1,2, Jeong SY1,2, Lee SW1,2, Lee J1,2, Ahn BC1,2.
1
From the Department of Nuclear Medicine, School of Medicine, Kyungpook National University.
2
Department of Nuclear Medicine, Kyungpook National University Hospital, Daegu, Republic of Korea.
- 연구소개
- 갑상선암의 방사성요오드치료시 침샘의 손상이 빈발하며 이 합병증은 구강건조증으로 평생동안 삶의질에 영향을 미칩니다. 본 연구는 침밑샘(이하선)을 도수 마시지를 시행하면 방사성요오드 치료시 이하선 손상을 억제할 수 있음을 보여준 연구입니다. 비교적 손쉽게 이용해 볼 수 있는 처치법으로 방사성요오드 치료를 시행하는 많은 기관에서 도움이 될 수 있습니다.
- 덧글달기
- 이전글 [Eur J Nucl Med Mol Imaging.] Diagnostic value of surveillance 18F-fluorodeoxyglucose PET/CT for detecting recurrent esophageal carcinoma after curative treatment.
- 다음글 [Endocr Pract.] PROGNOSTIC VALUE OF LYMPH NODE UPTAKE ON PRETREATMENT F-18 FDG PET/CT IN PATIENTS WITH N1B PAPILLARY THYROID CARCINOMA.
편집위원
갑상선암에서 이용되는 방사성요오드 치료는 유용한 임상효과에도 적지않은 환자에서 침샘손상을 발생시켜 장기적인 불편감을 발생시킨다. 침샘 마사지가 방사성요오드에 의한 침심손상을 감속시킴을 증명한 임상연구로 핵의학 연구자 및 갑상선암 치료 임상가에게 유용한 정보로 생각됨.
덧글달기닫기2019-09-27 15:08:23
등록
편집위원
갑상선암에서 이용되는 방사성요오드 치료는 유용한 임상효과에도 적지않은 환자에서 침샘손상을 발생시켜 장기적인 불편감을 발생시킨다. 침샘 마사지가 방사성요오드에 의한 침심손상을 감속시킴을 증명한 임상연구로 핵의학 연구자 및 갑상선암 치료 임상가에게 유용한 정보로 생각됨.
덧글달기닫기2019-10-30 17:10:25
등록