글로벌 연구동향
핵의학
- 2018년 09월호
[Clin Nucl Med.] Prognostic Significance of Interim 11C-Methionine PET/CT in Primary Central Nervous System Lymphoma.전남대화순병원 / 안서연, 권성영, 송상윤*, 양덕환*
- 출처
- Clin Nucl Med.
- 등재일
- 2018 Aug
- 저널이슈번호
- 43(8):e259-e264. doi: 10.1097/RLU.0000000000002154.
- 내용
Abstract
PURPOSE:
Primary central nervous system lymphoma (PCNSL) has a poor prognosis. There has been limited study evaluating the role of interim PET/CT in PCNSL. This prospective study investigated the interim response using sequential brain PET/CT with C-methionine (C-MET) to provide prognostic information during the treatment of PCNSL.MATERIALS AND METHODS:
A total of 26 immunocompetent patients recently diagnosed with PCNSL were evaluated. Brain MRI and C-MET PET/CT were performed at the time of diagnosis and after 4 cycles of high-dose methotrexate-based induction chemotherapy. Tumor-to-normal tissue (T/N) ratio and MTV were used to assess the interim response.RESULTS:
All patients had diffuse large B-cell lymphoma. No differences were observed in initial tumor volume or quantitative uptake among the International Extranodal Lymphoma Study Group groups. Higher International Extranodal Lymphoma Study Group risk scores were associated with higher median values for interim MTV and T/N ratios, as well as poor outcomes. After a median follow-up of 21 months, interim C-MET PET/CT assessments based on the quantitative T/N ratio and MTV predicted progression-free survival and overall survival, respectively. A high interim T/N ratio was significantly associated with decreased progression-free survival (hazards ratio, 3.68; P = 0.044).CONCLUSIONS:
Response assessments based on interim C-MET PET/CT could predict the therapeutic outcome of PCNSL.
Author informationAhn SY1, Kwon SY2, Jung SH1, Ahn JS1, Yoo SW2, Min JJ2, Bom HS2, Ki SY3, Kim HJ1, Lee JJ1, Song SY4, Yang DH1.
1
From the Departments of Hematology-Oncology.
2
Nuclear Medicine.
3
Radiology, and.
4
Thoracic and Cardiovascular Surgery, Chonnam National University Hwasun Hospital, Jeollanam-do, Republic of Korea.
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편집위원
CNS lymphoma (diffuse large B cell lymphoma) 에서 C-11 Methionine PET 영상에서 얻어진 종양의 MTV 및 T/N ratio가 환자의 예후를 예측할 수 있음을 보여준 임상연구 결과임. 종양학 의사 및 임상 핵의학자에게 유용한 정보를 제공할 것으로 생각되며, FDG 를 벗어난 PET tracer 연구의 관심을 끌 수 있는 연구로 보임.
덧글달기닫기2018-09-13 15:52:58
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