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Abstract

Hair loss is a common medical problem. In this study, we investigated the proliferation, migration, and growth factor expression of human dermal papilla (DP) cells in the presence or absence of treatment with mesenchymal stem cell extracellular vesicles (MSC-EVs). In addition, we tested the efficacy of MSC-EV treatment on hair growth in an animal model. MSC-EV treatment increased DP cell proliferation and migration, and elevated the levels of Bcl-2, phosphorylated Akt and ERK. In addition; DP cells treated with MSC-EVs displayed increased expression and secretion of VEGF and IGF-1. Intradermal injection of MSC-EVs into C57BL/6 mice promoted the conversion from telogen to anagen and increased expression of wnt3a, wnt5a and versican was demonstrated. The first time our results suggest that MSC-EVs have a potential to activate DP cells, prolonged survival, induce growth factor activation in vitro, and promotes hair growth in vivo.

Author information

Rajendran RL1, Gangadaran P1, Bak SS2, Oh JM1, Kalimuthu S1, Lee HW1, Baek SH1, Zhu L1, Sung YK2, Jeong SY1, Lee SW1, Lee J1, Ahn BC3.
1 Department of Nuclear Medicine, Kyungpook National University School of Medicine/Hospital, Daegu, 700-721, Republic of Korea.
2 Department of Immunology, Kyungpook National University School of Medicine, Daegu, 700-721, Republic of Korea.
3 Department of Nuclear Medicine, Kyungpook National University School of Medicine/Hospital, Daegu, 700-721, Republic of Korea. abc2000@knu.ac.kr.