방사선의학 웹진

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bstract

PURPOSE:

We investigated the value of early dynamic (ED) PET for the detection and characterization of bladder cancer.

METHODS:

Fifty-two bladder cancer patients were prospectively enrolled. The study protocol was composed of ED, whole-body (WB, 60 minutes after injection), and additional delayed (AD, 120 minutes after injection) PET acquisition. Early dynamic PET was acquired for 10 minutes and reconstructed as 5 frames at 2-minute intervals. A focal radiotracer accumulation confined to the bladder wall was considered as PET positive and referred for further quantitative measurement. SUVmax on ED (SUVmax, SUVmax, SUVmax, SUVmax, and SUVmax for 5 frames), WB (SUVmax), and AD PET (SUVmax) were measured. PET results were correlated with bladder cancer pathology variables.

RESULTS:

The sensitivities of ED, WB, and AD PET for bladder cancer were 84.6%, 57.7%, and 61.2%, respectively. The sensitivity of ED PET was significantly higher than that of WB (P = 0.002) and AD PET (P = 0.008). On ED PET, SUVmax was significantly correlated with muscle invasiveness, histological grade, and pathological tumor size (P = 0.018, P = 0.030, and P = 0.030). On WB and AD PET, only pathological tumor size showed significant positive correlation with SUVmax and SUVmax (P = 0.043 and P = 0.007).

CONCLUSIONS:

Early dynamic PET can help to detect and characterize bladder cancer.​

Author information

Yoon HJ1, Yoo J, Kim Y, Lee DH, Kim BS.

1 From the *Department of Nuclear Medicine, †Clinical Research Institute, and ‡Department of Urology, College of Medicine, Ewha Womans University, Seoul, Republic of Korea.