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Abstract

To explain gating of memory encoding, magnetoencephalography (MEG) was analyzed over multi-regional network of negative correlations between alpha band power during cue (cue-alpha) and gamma band power during item presentation (item-gamma) in Remember (R) and No-remember (NR) condition. Persistent homology with graph filtration on alpha-gamma correlation disclosed topological invariants to explain memory gating. Instruction compliance (R-hits minus NR-hits) was significantly related to negative coupling between the left superior occipital (cue-alpha) and the left dorsolateral superior frontal gyri (item-gamma) on permutation test, where the coupling was stronger in R than NR. In good memory performers (R-hits minus false alarm), the coupling was stronger in R than NR between the right posterior cingulate (cue-alpha) and the left fusiform gyri (item-gamma). Gating of memory encoding was dictated by inter-regional negative alpha-gamma coupling. Our graph filtration over MEG network revealed these inter-regional time-delayed cross-frequency connectivity serve gating of memory encoding. 

Author information​

Hahm J1,2,3, Lee H1,2, Park H1,2,3,4, Kang E5, Kim YK1,6,7, Chung CK8, Kang H1,6, Lee DS1,2,3,6,9.

1Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, 110-744, Korea.

2Institute of Radiation Medicine, Medical Research Center, Seoul National University, Seoul, 110-744, Korea.

3Interdisciplinary Program in Cognitive Science, Seoul National University, Seoul, 151-742, Korea.

4Institute of Neuroscience and Psychology, University of Glasgow, Glasgow, United Kingdom.

5Department of Psychology, Kangwon National University, Chuncheon-si, 200-701, Korea.

6Data Science for Knowledge Creation Research Center, Seoul National University, Seoul, 151-742, Korea.

7Department of Nuclear Medicine, Seoul National University Boramae Medical Center, 156-707, Seoul, Korea.

8MEG Center, Department of Neurosurgery, Seoul National University College of Medicine, Seoul, 110-744, Korea.

9Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, and College of Medicine or College of Pharmacy, Seoul National University, Seoul, 110-744, Korea.