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  • [PLoS One.] Treatment Outcome and Prognostic Molecular Markers of Supratentorial Primitive Neuroectodermal Tumors.

    연세의대/최서희, 김세훈, 조재호*

  • 출처
    PLoS One.
  • 등재일
    2016 Apr 13
  • 저널이슈번호
    11(4):e0153443.
  • 내용

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    Abstract

    BACKGROUND:

    To identify prognostic factors and define the optimal management of patients with supratentorial primitive neuroectodermal tumors (sPNETs), we investigated treatment outcomes and explored the prognostic value of specific molecular markers.

    METHODS:

    A total of 47 consecutive patients with pathologically confirmed sPNETs between May 1985 and June 2012 were included. Immunohistochemical analysis of LIN28, OLIG2, and Rad51 expression was performed and correlated with clinical outcome.

     

    RESULTS:

    With a median follow-up of 70 months, 5-year overall survival (OS) and progression-free survival (PFS) was 55.5% and 40%, respectively, for all patients. Age, surgical extent, and radiotherapy were significant prognostic factors for OS and PFS. Patients who received initially planned multimodal treatment without interruption (i.e., radiotherapy and surgery (≥subtotal resection), with or without chemotherapy) showed significantly higher 5-year OS (71.2%) and PFS (63.1%). In 29 patients with available tumor specimens, tumors with high expression of either LIN28 or OLIG2 or elevated level of Rad51 were significantly associated with poorer prognosis.

     

    CONCLUSIONS:

    We found that multimodal treatment improved outcomes for sPNET patients, especially when radiotherapy and ≥subtotal resection were part of the treatment regimen. Furthermore, we confirmed the prognostic significance of LIN28 and OLIG2 and revealed the potential role of Rad51 in sPNETs. 

     

    Author information

    Choi SH1, Kim SH2, Shim KW3, Han JW4, Choi J5, Kim DS3, Lyu CJ4, Kim JW6, Suh CO1, Cho J1.

    1Departments of Radiation Oncology, Yonsei University College of Medicine, Seoul, Korea.

    2Departments of Pathology, Yonsei University College of Medicine, Seoul, Korea.

    3Departments of Neurosurgery, Yonsei University College of Medicine, Seoul, Korea.

    4Departments of Pediatrics, Yonsei University College of Medicine, Seoul, Korea.

    5Department of Pharmacy, College of Pharmacy, Yonsei University College of Medicine, Seoul, Korea.

    6Department of Radiation Oncology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea. 

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