방사선의학 웹진

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Abstract
Background: We designed a multi-institutional retrospective study to investigate the previously unreported failure pattern, survivals, and prognostic factors after postoperative radiotherapy (PORT) in triple negative breast cancer (TNBC) patients in South Korea.

Materials and methods: We retrospectively reviewed 699 patients with TNBC who underwent PORT at six institutions between 2008 and 2010. The median follow-up period was 94 months (range: 7-192 months). There were 216, 380, and 100 patients in stages I, II, and III, respectively.

Results: After 94 months post-treatment, all patients with pathologic complete remission after neoadjuvant chemotherapy were alive without any failure. Distant metastasis was the main cause of failure. The 5-year overall survival rate was 91.4%, 5-year loco-regional relapse-free survival rate (LRRFS) was 92.3%, 5-year distant metastasis-free survival rate (DMFS) was 89.4%, and 5-year disease-free survival rate (DFS) was 85.2%. On multivariate (Cox) analysis, T and N stages were significant prognostic factors for survival, and lympho-vascular invasion (LVI) was a significant factor for LRRFS and DMFS. Ki-67 expression was significantly associated with LRRFS and DFS.

Conclusion: We verified that T and N stages, LVI, and Ki-67 expression were significantly associated with survival outcomes after PORT in TNBC.

Affiliations

Jin Hee Kim 1, Sang Jun Byun 1, Myeongsoo Kim 1, Kyung Hwan Shin 2, Dong Yun Kim 2 3, Han Byoel Lee 4, Tae Hyun Kim 5, Yeon Joo Kim 6, Yong Bae Kim 6, Jee Suk Chang 6, Kyubo Kim 7 8, Sun Young Lee 9
1Department of Radiation Oncology, Dongsan Hospital, Keimyung University School of Medicine, 1035 Dalgubeol-daero Dalseo-gu, Daegu 42601, Republic of Korea.
2Department of Radiation Oncology, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
3Department of Radiation Oncology, Chung-Ang University Hospital, Seoul 06973, Republic of Korea.
4Department of Surgery, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
5Department of Radiation Oncology, Proton Therapy Center, National Cancer Center, Goyang 10408, Republic of Korea.
6Department of Radiation Oncology, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.
7Department of Radiation Oncology, Ewha Womans University School of Medicine, Seoul 07804, Republic of Korea.
8Department of Radiation Oncology, Seoul National University Bundang Hospital, Seoul 03080, Republic of Korea.
9Department of Radiation Oncology, Chonbuk National University Hospital, Jeonju 54907, Republic of Korea.