방사선종양학

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  • [Radiat Oncol .] Treatment outcomes of stereotactic body radiation therapy for primary and metastatic sarcoma of the spine원발성 전이성 척추 육종에서 정위체부방사선치료 결과

    KIRAMS / 김은지, 공창배*

  • 출처
    Radiat Oncol .
  • 등재일
    2023 Sep 22
  • 저널이슈번호
    18(1):156. doi: 10.1186/s13014-023-02346-w.
  • 내용

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    Abstract
    Purpose: This study evaluated the treatment outcomes of spine stereotactic body radiation therapy (SBRT) in sarcoma patients.

    Materials and methods: A total of 44 sarcoma patients and 75 spinal lesions (6 primary tumors, 69 metastatic tumors) treated with SBRT were retrospectively reviewed between 2006 and 2017. The median radiation dose was 33 Gy (range, 18-45 Gy) in 3 fractions (range, 1-5) prescribed to the 75% isodose line.

    Results: The median follow-up duration was 18.2 months. The 1-year local control was 76.4%, and patients treated with single vertebral body were identified as a favorable prognostic factor on multivariate analyses. Progression-free survival at 1 year was 31.9%, with the interval between initial diagnosis and SBRT and extent of disease at the time of treatment being significant prognostic factors. The 1-year overall survival was 80.5%, and PTV and visceral metastases were independently associated with inferior overall survival.

    Conclusion: SBRT for spinal sarcoma is effective in achieving local control, particularly when treating a single vertebral level with a limited extent of disease involvement, resulting in an excellent control rate. The extent of disease at the time of SBRT is significantly correlated with survival outcomes and should be considered when treating spine sarcoma.

     

     

    Affiliations

    Eunji Kim 1 2, Mi-Sook Kim 2, Eun Kyung Paik 2, Ung-Kyu Chang 3, Chang-Bae Kong 4
    1Department of Radiation Oncology, Seoul Metropolitan Government - Seoul National University Boramae Medical Center, Seoul, Republic of Korea.
    2Department of Radiation Oncology, Korea Institute of Radiological and Medical Sciences, Seoul, Republic of Korea.
    3Department of Neurosurgery, Korea Institute of Radiological and Medical Sciences, Seoul, Republic of Korea.
    4Department of Orthopedic Surgery, Korea Institute of Radiological and Medical Sciences, 75, Nowon-ro, Nowon-gu, Seoul, 01812, Republic of Korea. cbkongmd@gmail.com.

  • 키워드
    Oligometastasis; Sarcoma; Spine; Stereotactic body radiation therapy.
  • 편집위원

    Spine 유래 sarcoma 환자에서 방사선치료 이후 결과에 대한 환자의 예후를 분석한 연구 결과로서, SBRT 방법 적용된 환자의 예후의 상관관계를 규명한 부분이 매우 흥미롭다고 생각됨

    2023-11-08 14:15:59

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