바로가기  >

Abstract
Background: To explore the therapeutic outcomes of CyberKnife based fractionated stereotactic radiotherapy (CKFRT) for patients with cerebral arteriovenous malformations (AVM).

Methods: Between January 2008 and October 2020, 45 patients underwent CKFRT for cerebral AVMs as a first treatment. The delineation of AVM targets included AVM nidus. The mean target volume was 4.07 cm3, and 9 lesions (20%) were larger than 10.0 cm3. The mean marginal dose was 24 Gy (range, 20-35 Gy). CKFRT was delivered in median 3 fractions (range, 2 ∼ 5 fractions). AVM obliteration following CKFRT was confirmed by magnetic resonance imaging or angiography.

Results: During a median follow-up of 47 (5-148) months, complete obliteration and partial obliteration of AVM after CKFRT were obtained in 23 (51%) and 13 (29%) patients, respectively. Median time to complete obliteration was 39 (15-63) months. The cumulative probability of complete obliteration rate at 3 years was 47%. Complete obliteration rate of AVM was associated with Radiosurgery-based AVM score, which was consisted of AVM volume, patients age, and AVM location. One (2%) patient had hemorrhage during the follow-up period.

Conclusions: CKFRT is an effective primary treatment for patients with cerebral AVMs with a low hemorrhage risk.

Affiliations

Jeongshim Lee 1, Woo Chul Kim 2, Hun Jung Kim 2, Hyeonseon Park 3
1Department of Radiation Oncology, Inha University Hospital, Inha University School of Medicine, Incheon, South Korea. Electronic address: jshimlee@inha.ac.kr.
2Department of Radiation Oncology, Inha University Hospital, Inha University School of Medicine, Incheon, South Korea.
3Department of Neurosurgery, Inha University Hospital, Inha University School of Medicine, Incheon, South Korea. Electronic address: hspark@inha.ac.kr.