글로벌 연구동향
방사선종양학
- 2023년 05월호
[J Geriatr Oncol.] Radiotherapy for older adults with facial non-melanoma skin cancer: Effectiveness in patients aged 80 and older제주의대 / 최진현, 박소현*
- 출처
- J Geriatr Oncol.
- 등재일
- 2023 Mar
- 저널이슈번호
- 14(2):101400. doi: 10.1016/j.jgo.2022.10.015. Epub 2022 Nov 10.
- 내용
Introduction
Non-melanoma skin cancer (NMSC) most often develops in areas of the skin regularly exposed to the sun and is distinguished from melanoma, which is more serious [[1]
]. The incidence of NMSC, including basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), continues to increase markedly with age, especially in adults >80 years old [[2]
].
Although excision is the main treatment for most operable NMSC, radiation therapy (RT), as an alternative to surgery, can be preferred for patients >60 years old who are not candidates for primary surgery for skin cancers [[3]
]. In addition, RT should be offered for lesions of the central face, lips, eyelids, and ears if surgery leads to inferior cosmetic or functional outcomes [[1]
]. Nevertheless, limited data have been reported on the effectiveness of radiation therapy in the older adults, and few studies have examined the tolerability of radiation therapy in patients with facial NMSC aged ≥80 years [[4]
].
Chronological age is a poor surrogate for functional status or comorbidity burden, which are known to lead to an increase in complications during treatment [[5]
]. These potential age-related barriers impact a patient's decision or ability to receive cancer treatment. In this study, we evaluated the role of RT in older adults with facial NMSC.Affiliations
Jinhyun Choi 1, So Hyun Park 2
1Department of Radiation Oncology, Jeju National University Hospital, Jeju University College of Medicine, South Korea.
2Department of Radiation Oncology, Jeju National University Hospital, Jeju University College of Medicine, South Korea. Electronic address: psh1012@gmail.com.
- 키워드
- Elderly patients; Non-melanoma skin cancer; Radiation therapy.
- 연구소개
- 기저 세포 암종(BCC) 및 편평 세포 암종(SCC)을 포함하는 비흑색종 피부암(NMSC)의 발병률은 특히 80세 이상의 나이에서 현저하게 증가합니다. 수술적 절제가 주요 치료법이지만 수술의 대안으로서 방사선 요법(RT)은 60세 이상이거나 피부암에 대한 1차 수술 대상자가 아닌 환자에게 선호될 수 있습니다. 또한 수술로 인해 미용적 또는 기능적 결과가 열등한 경우에도 방사선 요법이 효과적입니다. 이 연구는 안면 비흑색종 피부암 노인 환자에서 세기조절 방사선치료 후 임상적 효능을 증명하였습니다. 기대 수명이 길어지면서 노인 환자의 암 발병률이 높아지고 있습니다. 따라서 연령이 치료 의사 결정의 유일한 요인이 되어서는 안 되며 근치적 또는 완화적 치료에 관계 없이 안면 비흑색종 피부암이 있는 80세 이상의 환자에게 방사선치료가 안전하고 효과적으로 사용될 수 있음을 시사합니다.
- 덧글달기
- 이전글 [Eur J Surg Oncol .] Omission of axillary lymph node dissection in patients with ypN+ breast cancer after neoadjuvant chemotherapy: A retrospective multicenter study (KROG 21-06)
- 다음글 [Int J Radiat Oncol Biol Phys .] Randomized, Multicenter, Phase 3 Study of Accelerated Fraction Radiation Therapy With Concomitant Boost to the Gross Tumor Volume Compared With Conventional Fractionation in Concurrent Chemoradiation in Patients With Unresectable Stage III Non-Small Cell Lung Cancer: The Korean Radiation Oncology Group 09-03 Trial