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  • [Cancer Res Treat.] Chronological Analysis of Acute Hematological Outcomes after Proton and Photon Beam Craniospinal Irradiation in Pediatric Brain Tumors

    성균관의대 / 유규상, 임도훈*

  • 출처
    Cancer Res Treat.
  • 등재일
    2022 Jul
  • 저널이슈번호
    54(3):907-916. doi: 10.4143/crt.2021.332. Epub 2021 Oct 15.
  • 내용

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    Abstract
    Purpose: This study aimed to compare the early hematological dynamics and acute toxicities between proton beam craniospinal irradiation (PrCSI) and photon beam craniospinal irradiation (PhCSI) for pediatric brain tumors.

    Materials and methods: We retrospectively reviewed patients with pediatric brain tumors who received craniospinal irradiation (CSI). The average change in hemoglobin levels (ΔHbavg), absolute lymphocyte counts (ΔALCavg), and platelet counts (ΔPLTavg) from baseline values was evaluated and compared between the PrCSI and PhCSI groups at 1 and 2 weeks after the initiation of CSI, 1 week before and at the end of radiotherapy, and 3-4 weeks after the completion of radiotherapy using t test and mixed-model analysis.

    Results: The PrCSI and PhCSI groups consisted of 36 and 30 patients, respectively. There were no significant differences in ΔHbavg between the two groups at any timepoint. However, ΔALCavg and ΔPLTavg were significantly lower in the PhCSI group than in PrCSI group at every timepoint, demonstrating that PrCSI resulted in a significantly lower rate of decline and better recovery of absolute lymphocyte and platelet counts. The rate of grade 3 acute anemia was significantly lower in the PrCSI group than in in the PhCSI group.

    Conclusion: PrCSI showed a lower rate of decline and better recovery of absolute lymphocyte and platelet counts than PhCSI in the CSI for pediatric brain tumors. Grade 3 acute anemia was significantly less frequent in the PrCSI group than in the PhCSI group. Further large-scale studies are warranted to confirm these results

     

     

    Affiliations

    Gyu Sang Yoo  1 , Jeong Il Yu  1 , Sungkoo Cho  2 , Youngyih Han  1 , Yoonjin Oh  2 , Do Hoon Lim  1 , Hee Rim Nam  3 , Ji-Won Lee  4 , Ki-Woong Sung  4 , Hyung Jin Shin  5
    1 Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
    2 Department of Radiation Oncology, Samsung Medical Center, Seoul, Korea.
    3 Department of Radiation Oncology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
    4 Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
    5 Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

  • 키워드
    Craniospinal irradiation; Hematological outcome; Hemoglobin; Lymphocyte; Photon beam therapy; Platelet; Proton beam therapy.
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