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  • [Clin Breast Cancer.] Quantitative Changes in Skin Composition Parameters after Radiation Therapy According to Surgery Types Among Patients with Breast Cancer: A Prospective Study

    성균관의대 / 유규상, 강단비, 박원*

  • 출처
    Clin Breast Cancer.
  • 등재일
    2022 Feb
  • 저널이슈번호
    22(2):e224-e231. doi: 10.1016/j.clbc.2021.06.013. Epub 2021 Jul 19
  • 내용

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    Abstract
    Background: In the current study, we sought to evaluate and compare the objective changes in biophysical parameters and patient-reported outcomes following radiation therapy (RT) in patients with breast cancer who underwent breast-conserving surgery (BCS) or modified radical mastectomy (MRM).

    Materials and methods: Patients older than 18 years, with stage I to III breast cancer, who were expected to receive RT were recruited between August 2015 and March 2019. Skin hydration, sebum content, pigmentation, and elasticity of the irradiated and unirradiated breast or chest wall were assessed using a noninvasive bioengineering device. Assessments were performed before the initiation of RT (T0); after the 5th (T1), 15th (T2), and 25th (T3) fractions; and 1 (T4) and 3 months (T5) after the completion of RT. Patient-reported outcomes were also evaluated using Radiation Dermatitis Assessment for Breast Cancer 11.

    Results: Hydration and sebum levels on the irradiated breast decreased during RT and had not returned to baseline at T5. Erythema on the irradiated breast increased two-fold between T0 and T3, and melanin levels were significantly higher than those at baseline and those of the contralateral unirradiated breast until T5 (106.0 vs. 115.8, P = .03). More than half of the patients continued to report skin color changes, dryness, and pain after RT. The erythema in the irradiated site at T1 was significantly higher in the MRM group than in the BCS group (P for interaction = .04), while there were no significant differences in the changes of the other parameters.

    Conclusion: RT-induced changes in hydration, sebum, and melanin, and the majority of patient-reported pain, color changes, and dryness, even 3 months after the completion of treatment. There were no remarkable differences in the measurable skin parameters according to the surgery type, with the exception of erythema, which was higher in the MRM group 1 week after the start of RT.

     

     

    Affiliations

    Gyu Sang Yoo  1 , Danbee Kang  2 , Im-Ryung Kim  3 , Hyeokgon Park  4 , Eunjoo Kim  4 , Won Kyung Cho  1 , Haeyoung Kim  1 , Doo Ho Choi  1 , Juhee Cho Ma  5 , Won Park  6
    1 Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea.
    2 Center for Clinical Epidemiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea; Department of Clinical Research Design and Evaluation, SAIHST, Sungkyunkwan University, Seoul 06351, South Korea.
    3 Cancer Education Center, Samsung Comprehensive Cancer Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea.
    4 Skin Research Institute, AMOREPACIFIC Corporation R&D Center, Youngin 17074, Korea.
    5 Center for Clinical Epidemiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea; Department of Clinical Research Design and Evaluation, SAIHST, Sungkyunkwan University, Seoul 06351, South Korea; Cancer Education Center, Samsung Comprehensive Cancer Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea; Departments of Epidemiology and Health, Behavior, and Society, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
    6 Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea. Electronic address: wonro.park@samsung.com.

  • 키워드
    Breast neoplasms; Dermatitis; Measurement; Patient-reported outcome; Radiotherapy.
  • 편집위원

    유방암 방사선치료 후 흔히 관찰되는 피부 변화를 Multi-Probe를 이용하여 정량적으로 측정한 결과를 분석한 논문

    2022-03-18 10:30:19

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