글로벌 연구동향
방사선종양학
- 2019년 06월호
[In Vivo.] Combined Chemoradiotherapy-induced Weight Loss Decreases Survival in Locally Advanced Non-small Cell Lung Cancer Patients.서울의대 / 김이준, 송창훈, 김재성*
- 출처
- In Vivo.
- 등재일
- 2019 May-Jun
- 저널이슈번호
- 33(3):955-961. doi: 10.21873/invivo.11564.
- 내용
Abstract
BACKGROUND/AIM:
The aim of the study was to investigate the prognostic impact and predictors of weight loss during definitive radiotherapy in non-small cell lung cancer (NSCLC) patients.PATIENTS AND METHODS:
A total of 125 NSCLC patients (2003-2016) who had received definitive radiotherapy were included in the study. Multivariate analyses were performed to estimate prognostic values. Predictors for weight loss were analyzed.RESULTS:
The median survival of patients with weight loss (>5%) during radiotherapy and for those without any significant weight loss was 15.6 and 33 months, respectively (p=0.015). Non-intensity modulated radiotherapy (IMRT) technique was the only factor associated with weight loss (p=0.039). Weight loss was a poor prognostic factor for overall survival (OS) (hazard ratio [HR] 2.072, p=0.018), and IMRT was a favorable prognostic factor (HR=0.192, p=0.029).CONCLUSION:
During definitive radiotherapy, weight loss of >5% resulted in decreased OS rate in locally advanced NSCLC. IMRT might increase OS rate by minimizing weight loss.
Author informationKim YJ#1,2,3, Song C#1, Eom KY1, Kim IA1, Kim JS4.
1
Department of Radiation Oncology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam-si, Republic of Korea.
2
Center for Precision Medicine, Seoul National University Hospital, Seoul, Republic of Korea.
3
Department of Radiation Oncology, Graduate School of Medicine, Ewha Womans University, Seoul, Republic of Korea.
4
Department of Radiation Oncology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam-si, Republic of Korea jskim@snubh.org.
#
Contributed equally
- 키워드
- Body weight; IMRT; definitive radiotherapy; non-small cell lung cancer
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편집위원
비소세포성 폐암에서 방사선치료 중 체중감소가 생존율과 연관되고 IMRT가 체중감소 예방에 도움이 된다는 흥미로운 결과를 보여준 논문입니다. 하지만 후향적 연구로 IMRT와 치료독성 사이의 연관성을 찾지 못한 한계가 있습니다.
덧글달기닫기2019-06-24 13:45:41
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